A Sao 1 July 1969 to 30 June 1969 RESEARCH PROJECT AT (11-1) 1784 mA) ! | ty ! idl | 407560 TITLE OF INVESTIGATION ! iu Au | itt Nie A Study of the Physiological Function and etn uli sal i Radioactive Iodine iistological Changes in Thyroids Irmadiated with oythee ghia SH iit PRIICIPAL INVESTIGATOR Brown i1. Dobyns, 4. D., Ph. D. = wi ie Professor of Surgery, Case Western Reserve University a il © Submitted 30 June 1969 a i ER perm at | Case Westarn Reserve University School of Medicine at Cleveland Metropolitan General Hospital Observations have continued in a variety of areas in both =.0. md as previously outlined and reported in great detail one year a>. ani ’ Effects of 1311 Irradiation on the Thyroid in Clinical Subjects with 2 We continue to collect very detailed data on selecte. patimts treated wit 131I for hyperthyroidian 90 that the clinical effects of the 131I can ulfimately be related to the behavior of 1511 that was observed in that individual. This :s done in an effort to get a better understanding of why the effective dos cof 1527 per estimated gram of thyroid tissue is so variable from individual to idividcz Inspite of therapeutic doses, which are calculated to be just sufficient [to brig the hyperthyroidian under control, we still observe far too high an incidens y i of » not weeks or months, but years after the mdiation is deJivered. Since the responsible investigator is in charge of all 151I therapy in tps hospital, these is an oppermmity to study selected patients in great det} The following observations are made: 1) Careful pretreatment charucterikatico of the glard and the patient, not only with respect to the uptake of a traces of 131], but a variety of observations on factors that may explain differengs amrg patients. 2) Determination of the amount of the treatment dose taken up by the thyroid, followed by almost daily measurements over the gland thereafter fo determine the disappearance curve of the isotope from the glard. 3) ripe observations on the concentration of 131Z in the serum as it relates to the thyroid at given times. 4%) Determination of the extractable and non-extheccab fractions in the blood (butanol) and in same cases the serial quantitative Getermination of iodinated compounds in the serum as the madiaticn effect! takes place. 5S) Similar observations are made on the total urinary excretio pf +311 BEST COPY AVAILABLE