loc. o EXPOSED lo © UNEXPOSED 30 — a COMBINED WITH STANDARD | | . . : ® UNEXPOSED 0 COMBINED o EXPOSED 379 20,3901 7 * * ¥? 23.830 + 0.5234 x ERROR MEANS r=0.4447 ** 201 } y? 2.24 + 0.671 « 42.31 | | i mg PERCENT | PERCENT 194 g/kg BODY WEIGHT PERCENT | FO — 1.52 80 — * * CORRELATION WITH AGE SIGNIFICANT AT I% LEVEL | 9O— * * CORRELATION WITH AGE SIGNIFICANT AT 1% LEVEL 1Qr~ ee | | | 20 30 40 50 60 AGE 70 8c | ot 90 Figure 46. Potassium, males (1961 and 1965). oe : 90 80 f- I | T COMBINED WEIGHTED DATA * 2 EXPOSED @ UNEXPOSED 3 COMBINED WITH STANDARD ERROR MEANS | 7Oh PERCENT AGING — ing tissue. In the Marshallese the high incidence of adenomatoid goiter in the more rapidly pro- | - 40 liferating thyroid glands of the children maypos- sibly represent premature appearanceoflesions which are knownto occurlater in life and thus in a sense represent an aging process. On the other = 30- * COEFFICIENT FOR AGE CORRELATION OF EACH CRITERION USED TO WEIGHT SCORES BEFORE SUMMING 20/- lee 30 occurs relatively soon after irradiation, while malignant lesions of the skin would not become manifest until later in this more slowly proliferat- 4 50; | 80 proliferating cells of the bone marrow, leukemia | 60 AGE | 70 related to rapidity of cell proliferation (generation cycle) in a particular tissue, 1.e., with more rapidly | : | 60 manifest. One aspect of this phenomenon may be 7 y? 0.51+0.38 x +0.01 x? 50 at an earlier time than it would ordinarily be | a r= 0,99 ** nl 40 Figure 47. Cholesterol (1957). T o 30 i 7 4 hand, the fact that no tumors (except benign nevi) have been notedin the heavily irradiated skin of these people might indicate a longer induction period dueto slowercell turnover of the skin. 1Or ; ol 20 ** CORRELATION WITH AGE 7 SIGNIFICANT AT 1% LEVEL | 30 | 40 | 50 60 AGE | 70 | 80 Figure 48. Biological age scores. | Lo 90 In considering future aging studies in the Marshallese it is hoped that moresensitive tests of vigor and organ function suitable to the condi- tions of study may be used. However, it must be borne in mind that such subtle aging effects may not become detectable by ordinaryclinical means