Tabie 21
Kinetic Analysis of '**{ Studies
Location and year
Marshalls. March 1965
Subject No,
Exposed*
Unexposed*
BNL, June 1965
Marshalls, March 1966
2 pre TSH
per day
L.10
(0.34-2.57)
0.81
(O.17-1.99)
per day
0.67
(0.33-1.27)
0.79
Thyroid
fraction‘
Iodide
space,
liters
0.40
(0.250.635 )
0.52
(0.23+1.47)
(0.26-0.77)
0.80
Lig
1.71
0.41
20 pre TSH
post TSH
2.12
1.10
2.30
1.81
0.49
0.62
64 pre TSH
post TSH
1.88
0.81
1.08
1.56
0.36
0.66
3
0.52
0.005
0.01
5
0.86
0.14
0.14
1.13
0.15
0.42
2 (partial thyroidectomy)
1.20
Thyroid,°
post TSH
69 (partial thyroidectomy)
BNL, June 1966
Urine,’
0.60
33.3
1.53
0.92
0.37
20.0
61 (on thyroxine)
1.26
0.58
0.31
29.0
54
0.50
0.69
0.58
65
1.08
0.72
0.40
20.4
59 (on thyroxine)
1.65
0.10
0.06
16.9
42 pre TSH
post TSH
1.87
0.69
1.29
1.30
0.41
0.65
61 pre TSH
post TSH
0.13
0.50
0.48
1.67
0.78
0.77
33 pre TSH
post TSH
0.20
0.45
0.97
1.57
0.82
0.78
65 pre TSH
post TSH
1.83
2.35
0.82
1.14
0.31
0.33
39 pre TSH
post TSH
3.53
1.29
1.51
3.09
0.30
0.71
*Fraction of extrathyroidal iodide excreted in the urine per day (A,,).
"Fraction of extrathyroidal iodide transferred to the thyroid per day (A,,).
*Theoretical thyroid uptake, A.,/(Ao.+As1)“Mean and range of 12 subjects.
*Mean and range of 9 subjects.
signs of hypothyroidism: coarse facial features, dry
skin, and Achilles’ reflexes with typical sluggish
return. There was no palpable thyroid tissue. They
did not show apparent mentalretardation. TSH
levels (Table 20) were markedly elevated in both
boys, corroborating the presence of primary hypo-
thyroidism. Figure 28 shows bone age retardation
in one of these boys. Typical bone dysgenesis associated with hypothyroidism‘? was noted in 1965
in these boys. Figure 29 shows such changesin the
heads of the humeri in one case (No. 5).
From Table 20 indications can be seen that several other children with thyroid abnormalities
(subject Nos. 2, 20, 33, and 65), some of whom