cece Roca finales expeerd at <5 yn old am Casts cat Nea, 34 caged at | yt old 65 GAME 1972) e - a . interesting that radiochemical analysis of bone samples showed “Se levels about the same as in people living in New York. 4 Neatragiil, yw la-3 Lamnphocstes x» hu-3 Retrospective study ofhematological data. The hematulogical data gathered over the 18-year period on the subject with leukemia (No. 54) were compared with the mean levels of 8 other Rongelap boys exposed at <5 years of age and of 8 unexposed boys in the same age range (Figure 52). The percentage differences in mean peripheral blood levels between subject No, 54 and his exposed peers are given in Table 36 fur the first year and for the subsequent years, The subject with leukemia showed greater depression of neutrophils both during the immediale pust-exposure period and in subsequent years, The least dilference appearec to be in the erythropuictic system, Morphological studies of peripheral bluod smears revealed no significant abnormalities until the development of leukemia; unfortunately Vine afiet expraure Vhatehas ba-# a Cnespiuecd tales of sae age were Nout ood maerespened at <5 yn poe Counts on No. Scape ot foyer (AMIE bs) no bone marrow examinations had been made before. Since the Marshallese children are prone to frequent infections associated with granulocytosis, it wasof interest to compare this response in the subject with leukemia and in the other exposed boys. The records showed that the white cell count cxceeded 10,000 a total of 36 times in 131 counts (27%) in the other 8 exposed boys and only once 4 F in 18 counts (9%) in subject Ne. 34, However, if this indicated a reduction in narrow reserve in this boy, the reduction apparently was insufliciens to result in anyillness serious enough to require hospitalization. Other data related to leukemia were gener- SYS” bo ft a > Ninothe de 8 IZ lo ally negative in subject No. 54, including alkaline Veur ‘Ditne alter expen i = -_= FI phosphatase levels of neutrophils, basophil counts, Australia antigen, and blood proteins (except for I a slightly elevated gamma globulin level, whichis common inthe Marshallese), Chromusome stud- porece Nob ales oxpemedd at <5 vreidd of . — Neo, dbenpemeccdat lb snold y ANLE TUT) |e Unespreed tigles ad wane dee ex of the peripheral blood made 12 vears aficr ex- posure and of the bone marrow during his terme - te IT ~~7 i. hal loess did not show aneuploidy or structural changes of the chromosomes. However, increased chromosome breakave (11% of the cells) was noted terminally, which may have been related to radiahoa exposure to chemotherapy, or possibly to bis disease, Discussion, Ue is possible that radiation exposure was involved in the ediology of teukemia in subject No. 34. Radiation exposure has long been ll! assogiated with the development of this disease (in Vean physicians, particularly radiologists 147-44" in pa. ‘Vite adie espeeure Viuure $2. Mean level of WEG, lwinphocytes, neulra- Phils, platclem, hematocrit, and neutrophil lytiphacyte ratio for subject with leukemia (No. 2b solid line in each case} compared witli those of exposed (= - -) aud wines: gamed (— = <=) boys diagune age range. over 1 ycarssince exposure, eK bee, ‘ Vr a Fe ste. ie, Ie : . nay Neer a a ~e . re Re, a J een " . "8° T DEO, URINE oe nS Per TN ROY 4 I +ebaRe . ‘ Newt hinph ao te NT Nag heN! Fr cet ‘ “Vettes? iy wth + Le owe Vicaperd uals of sane aye