vl thyroid sions ts tere recent. has not been on treatment long enough for evaluation. The veatere tineat until cave was not placed on thyroxine a atte: nodules had been detected The rord lesions descloped di ses eral persons w hoe were presume abl taking thea thyroul medication regular and who appesred to be cuthycoid with nord theroving fevels, on the oder Iban. Uy reid sod. les disappeared in twa cases (Nas ab and 10h dari thy rosine treatient Gan the Latter case, dhe. recurced and were surgically remaved) 1. Follow-up Caretal follow-ap studies on the subjects whe ‘Tripler had cancer. including whole-body scans Army Medical Genter, have shawn no signs of te. currence, No clear-cut evidence bas been seen al! further development of nodulaicines inthe theroid remnants in the benign cases. Because papillary thvroid carcinoma progresses very slowly, Jong continued follow-up obsery ation is accessary. No deaths or acute ilnesses have been assact ated with the thyroid abooraalities. Morbidity has been related to the development af reduced thyroid function resulting in varsing degrees of by pothyroidisin and inane case of hy poparathyroidism: follow mig thyvraidectoms “The lack of stat compliance with the thy rad treatment progrin in the operated cases involves the potential danger that seriaus hypothyroidism may develop, partic. ularly in patients living oa the outer islands and therefore lew trequently seen, raid funetion has been greath ruproved by the Gee ol achowmnrinaassay teehoiaes len nieisue ine Vy. Py crriradoths ronnie. ad PSELSSStack wot serunodoproterns, whieh had resulted re artehectiial elesauons ai dhe serum PRE an the Naesdiadlese. are dhiscussed) below. is abe mere eee cent imeasurements of thvrasine- binding protects wid scour Gav rontesbatin Staches of disroid funetion have abso ane taded testo nadhorodine apiike and exerction on sev: craboccastons. bo dhe fieldl these were done wiete a soumew hat peiniive apparatus (FPigare $81 '] Awaused to miniimiize the dase tothe thyroid. Mace estensive and sophisticated: tests were done on par Hents brought ta BND, tor evaliation priot testi gery clewhere. “These inehided: testy af Uis rail radiotoding uptake and scans (lechnetiam ey before and after TSEPstinulstion: determination of basal metibolisin rate, cholesterol, surihivie. globulin antibody levels; and a variety of clinical chemistry tests. Faanumber of cases ua small amount of MU was administered prior to sargers andthe finetion ofescised Uhvraid lesions aad sare rounding tissies was studied by iite liouriepbas One Herve; teald man (Na. 40) bredly developed acute thyroiditis atter TSUP adaninistriation 2. Studies of Exposed Rongelap People With Thyroid Abnormalities Evidence of thyroid: by pofunction and reduced reserve was scen in adew of the children prior to surgery (Nos. 2.20, 34. aad 657 aod tea greater degree in che two boss whe deselaped ins sedema E. STUDIES OF THYROID FUNCTION* 1. Procedures Measurement of circulating thyroid hormone has been an important part of the evaluation of thyroid function in these surveys. During thefirst 10 vears it was done by PRE analysis and subsequently by jou-exchange chromatography(thy. roxine by coluniny. Since 1972 evaluation of thy° Thyroid uptake studies were done at Rongelap an [90ane Wits Dr J.B Ralbandin band 7 tbv De J Robbins se BND. thycond function stuiies were done ts Dr EEL. Sudan PE determinations were nade by the Clinical Chemastry Sectioty at BNE. and by Kio Science Laboratories, Nan Nuss, Calif. who also did other secum sanding analyses band baby KEAN, and dia. Iwrable Ty. TSH. and PBC by revere- tow clectrophoress were analy eed by Oe. PUR. Lassen atthe Causvcruty of Prtsburgh and taore recently at the Peter Bent Bigham Hospital, besten PGR analves by REN was done be Dre ME Gershengorn and J. Rob: fons, and TG analysis by Dee M Izume and Jt. Bauheu. Figure 38. Plvroid function testing under Geld conditions, [Hib