but, because of age differences and other factors Group Nu. peuple® No. cus a Na, cas % previously stated, covariance must be climinated fom the date before these observations can be evaluated. (Neuropathy was evaluated an the basis of history of parcsthesias and/or objective abnormatisies it rellexes and sensory percepion.) The Sinited data available didi not suggest evidence for increased retinopathyor peripheral vas- Rongelap and Uticik 373 los 27.5 ao 75 with absence of acute svinptonis, ketosis, and abe Male Female bie ta 4 ol 7 29 7 1 ws 5.1 wwhate dependence on tasulin treatunent. Ohese bie att St + a Uiirik 201 37 4 244 wa Rangelap and Ciisik people (genetics) of beacon places of residence (covironmental intlucnace), and there is no evidence that radiation exposure lies plaved a part ia the pathogenesis, The dillcrences Resicing at** Majuro 120 37 MY 38 ul bi 2h wouter islands” and the district comers are consid. erable and mvght well play a significant role in 2 Kongelup Ebese Ronuelap Usirsk I. ta 2s low 10 4 more closely resembles maturity onset diabetes Whe dite da net suugest any differences between in dict and general living conditions between the lie a ‘ “Tnchides 10 subjects from: ouier atolls, paarricd to Ron gelup and Carik people. *tncludes both Rougelap and Ciisik people residing al these lava tions. Marshall Islands is considerable and is probably greater than in any other population groups exe cept possibly certain American E[ndian groups! Although same previous reports have indicated a high incidence of diabetes in some Polynesian populations6 others have suguested a law incidence 38+ The overall incidence of diabetics was 20%, and ~ Hoof these patients were unaware of their ab- normality. The average age of the diabetics was considerably greater than that of the noodiabetion, The disease appears to be as comman in males as in fesides, but a definite statement must await pathouenesis. However, analysis of this factor is diilicult because of the mobility of the people, wha constantly move between home iskind and de centers; the place where an individual is exam, ined may not be where he has spent ue major part uf, say, the bast 10 years, Despite the limitations, the preliminary results are considered to be of suflicient interest to warrant amare careful and complete investigauen, Additional observations will be made to provide the missing information and to obtain more objec: tive data regarding the mcidence of neaopatiy, cataracts, and retinopathy ia these paticnts. Uhe Risulin rospoasc toa glucose challenge would also be of interest in assessing same of the factors that might be dapartaatia the coolopy of diabetes in the Muasrsdiall Islas. The csuninations are by nccessity restrictca to Rongelip and Uiiik peaple. When the Eniwetok aad Bikind peaple returaie thete home iskanes in Mere CommMOen ta women than in inen, and the wallicient number, the dinbetos investigations Quay be expanded te cover these groups. subjects. Cataracts scemed to be much mare commonin the dighcGcs than ja the noadiabetics, but H. CHROMOSOME AND GENETIC STUDIES campletion of the data analysis. Obesity was much data iadicate an increased incidcace among obese this would certabily be alluenced by the older age of the diabetic population, No definite diflercnce was seen in the incidence of cataracts among individuais known tu have diabetes compared with those in whoa the diagnosis was made during this survey. Nsignificanuly higher percent of the dia- 1. Studies of Chromosomes for Radiation Effects fa 1900 chromesome preparations were ob- tained from lyiiphocytes cultured from the periph eral blood of 44 exposed (21, age << 20;+ 22, =o, age be ee ee Son-obest cular disease among the diahetios, “Vhe disease etl ee Diabetes Cilycamuria with normal bohowal seguir ema ee ee ee Diabries Survey: Preliminary Results, [674 Ride tele eel 84 betics than of the nondiabetics had ncurepathy, Table 20