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Bloud cell changes. Vhe persistent lag in complete
recovery of leukocytes was believed to rellect re-
duced bone marrow reserve and therclore reduced
iunolayical reserve. The apparent reecat recov
eryof henopuiesis in the exposed people to cootrol
levels may indicate an improvement in their in
munological stitus. Vable 1 shows that reduc.
tions in lymphocytes and platclers and an increase
in sedimentation rates were correlated with ine
creasing age da the Marshallese,
Pannnoprotems, Giamunoclectropharetic analysis
af scrunt proteias in 1962 showed neither a paras
proteinenia tor atypical picture of autibody deficieney syndrome. but a high frequency ofsome of
fu0
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we
Bk
T
T
T
Candaned weighted data”
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T
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9 Exjoned
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C Ganlaned with tanked
errs paras
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re Dee
yw.) +058 040.08 a7
Penent aging
‘
duced immunological surveillance. Our interest in
inmnunelovical capacity is related alse to the con.
sideration that impairment of inerunity is thoughe
ta be associated with the aging process.
Antibody response, Three years after exposure a
number of exposed and unexposed Rongclap
people were tested for antibody response ta primary and sccondary tetanus toxoid inoculations,
with a mouse used for loxin-antitoxin assay of
wrui.8* “The difference between the exposed and
unexposed groups was not significant.
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*Cartiannt far age
custelativn ul cach
cntenun wed to weight
wures before suluniiig
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**Correlation with age
i
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signiteant al 1% level
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40
Age
the Inununogtobulias was nosed." * Coniplement
Figure 25. Biological aye scores."
(anepidciic of tis clisease later accurred ia 172),
tured from peripheral blood showed a definite decrease Of responsiveness with increasing age of the
individual (Vaile 18 and Figure 24) but no definite difference between exposed and unexposed
groups.”[na more recent study, acetylation of
nuclei of PILA-treated Ivmiphocytes was measured
aM Various times as a function of lvaaphocyte transformation and of aging.4! Decreased acetylation of
nuclei is associated with increasing age and is
fixation studies showed the Afarsballese to bave
antibodies ta iost viruses except Asian balluenza
The antibody tiers appeared somewhat lawer in
the exposed people
‘The older peaple had higher levels of ganna
globulins but sliuhtly deercased albumin levels
(1969).Panodi fusion studios shawed
that the rise in gamuna globulin levels was paral-
leled by an increase in imunoglobulia.t Vhe in
crease in lyG proiety was the most pronounced, and
it shaawweal signiticant correlation with age (suka),
Vhe inerease in Ko light chains was alsa signifi:
cantly correlated with age. Vhe inimunoglobubin
levels were mare depresscd in the exposed group,
particularly those of iG, bl, and blight chains
(Vable 1h). owever, by 97 the gamana globu-
bie levels inthe exposed people were nearly the
same ais the unexposed (Table 19).
Larmphocyte fan tien, “Vests on the phstohemag-
glutinin (PEE) stinmibanion of fvmiphocytes cule
De, MD. Srerssee at BEND. dial thar rials wes,
BP dew, KR. Dbisnbee and NV. Pi geeae ot thee Stee Kaul Creme bodes
fore tied these sited ya,
"Vhene stushes were dhe by Dos. Pb. Baden aid K Wonis
ed thee Nuotie etal Clete Dersciengh boda Caer
NORey ue?
TP £~nAes
roughly parallel to the decrease in lymphocyte
transformation. Total acetate incorporation in ue
nucle during the first hour of cullure was corre-
fated with acetylation of histones, but by 20 hr
acetylation of other nuclear materials had also
oecurred.
Chrameume coats, Ia 1909 chromosame counts
were made on PLLN-stimulated Ivimphoevtes cultured from peripheral bleod fron: 78 unexposed
and 27 exposed Rongelap people.“ Both hypodiploid and polyploid levels were faund to be related
to the subject's age. Females > 50 and exposed
males >O0 had ~ 1.5 thes as many hypodiplords as chad the younger subjects; polyploid levels
were sharply reduced in all subjects > 90. Hy-
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