REY a: hone narrow and chyromesaime studies aad the dee velopment of a case of leukosnia tend to support “this Comteution, qv t Keyresion line Sigg Mere Manhallee Caucasian ion Pacific NV. = 0.95 + 0.000 (TRW) KCV2 0.0K +0074 (TBW) BV 2064740115 (HW) ROYS018 + OUST BW) BV £05537 +0076THW) [OV s 0.17494 GOICTRW) PIV i) ee Gu7e2 TAY [ROW 0.17 + OY CT, a’ Nidan, liens sete “, ~ aw ere pe a Sy re pues tnulative perceatage of neutrophils, lymphocytes, and platelets at various tines. From these data it Sppcars that hemepoichc recovery inthe exposed Wroups was incomplete during the first 13 years alice exposure, Since dhat time the levels in the expesed group have been about the same asin the unexposed group. On the basis of KIC, hematyert, and hewoglobin determinations, ery Uiropoielie function has been about the same in the exposed and in the comparison population. Phe lag in recovery Of leukocytes and platelets may reprewt residual bone auugrraw jajury. The results of 3. Bone Marrow Atthough bone tiurrow cxaminsiions at 6 Thagths post expesure showed ne pros abnormal ilies, sncans on lourespascd Runyclap people 10 years kuter showed alteration ian the myeloid. crvthroid catio in three of thea, manifested by an inereascd nanber uf eed och preeursors. da additen te hyperplasia. die tidings included abnor. makities of Chromatin material with doubbe auch atab an increased nunber af niitetic figures in the ornabbastic series (sce Fiiures $4 and 1), 5) Oe. casionally, bilaubed Iyvmphocyies have been noted inthe peripheral bigod af some exposed people. 4. Other Hematological Findings “Total blood volume and red cell volume were studied 10 yours after exposure!!!" No differences were found beaween exposed and wnexpesed Rone selap groups, bat it was nated that blood valume and red ecll velume tended tube reduced in many Marshallese compared with Americans] (see Fig. ure 16)! Severabarher hematological observa: ions, net related to radbation exposure. were noted, Losinopbilia >5% in anare than half the people has been a consistent finding. This could be ac. counted for anly partly an the basis of intestinal parasivisin and may be related abso to mamerous fungus intections af the skin aiid other chronic ine fections, Other findings possibly rehired to chronic Infections are above-normal sedimentation rates wd bigh gamma globulin levels (both tending to increas? with ave). Varving degrees of anemia have been seen occasionally, particularly in wo- *Phese studies were dhine ba De 1M. Mever, Veterans Ab Hnistration Mapital. Aeaklyn, NOV. and be. WOE. Sin. Una. senity of Caliernia at Hea beley, Cate a mee ° -” aie “" a 4 uv tu OFNbeawe 1 a BEY COE, Vd OME serseee Marmhallow of mm Cate asta 1 1 al #) Hn Bae ati i we +a) Vatal deals water, liters Figure 16. men of childbearing age, Price Jones sizing of red cells in these cases showed a slight microcytic tend. ency.* Tron delicicney apparently was not the cause since serum iron usually was in the pormal range.® Keticulocyte counts have not been significantiv icreased in either the exposed or unesaposed population. Miacroeytic ancinia bas nut been seen, Vitansin Bye levels have been unusually high in the Marshallese*; the cause of this is unknown but does not appear tu be related tu liver disease or keukemia. The sickling trait has not been seenin the Marshallese examined. D. SUBSEQUENT COURSE OF SKIN LESIONS The residual skin lesions noted in the Rongclap and Ailingnae people since the initial lesions are listed in Table 15. During the first vear many of the healed arcas, particularly on the back of the neck, showed a roughening (rugosity) and bluish. black pigmentation, which became less noticeable with time (see Figures 17 and '8). Deeper lesions exhibited carly residual scarring and lack of pig-