determine whetha such chunces are cauzed by virus alons, As I nenticned, it 13 pessible that such chanzea résult fron internal radiation via fission products produced in the liver and it 4s also possible that the marrow or the mesodermal or mesenchyme organs, which ere susceptible to radiation, wore indirectly attacked and that those changes followed. Taig point must be carcfully studied fron various angles, Let me add that if any virua is found in Hr. liver, part of which I sent to Dr. Jo for detoction of virus, I will have to reconsider the case. Hoover wa cannot deny that in the case of Mr. there was sons Jiver dysfunction caused by redioactive clerents of which we have knom nothing until row, fr. guomioed to pepatis dysfuncticn but it reatna an Acsortent task to discover the true charseter of rediooctive chinzes in the liver. For this purpose, I gineerely hope thit you «ill cneourage and guide us. 43 I mentioned at tha ta;inning, Er. cecnditioa had been carious for cuite a loag tin-2. Ordinarily he would have died carlier, Thorefere I fecl that there ucre certain serious corpho= legical chances which hadrot been recogniced omitil now. For instances the myootie involvement could ba raised for discussicn and wo must consider very carefully the chance that it might have disguised inporte ent findinzs on radintion sickness, Anything remaining after those etasicor.tions would bo radiorctive morpholoeitcai chinzes, at the tine of Ire desth.e Titre is no doit thet the roin crau3zes of d2.th wore c..tosure to tho redfcictive Birkin’ ash and .orphologi¢cal cionces following the e-posure, Purtkesa: De. Chr-oto, can vo not e-noct to sea the rcsults of the rvdiorutotecph of tho or.:°23? Chanotos: I have been exazining the radioautograph in cooperation with Poofessor Ken of Chiba University, and I expect to discuss the cata in a ecuplo of days wivh the Kimura Laboratory end Dr. Eto of the premedical leboratory. Tho Kirura Laboratory will probably mke én onnouncenent eLout it. The newspepors reported that the Kicura group observed reaotion in thea kidney and the liver. Dr. Ohashi, what are the findings on our ani-al experinant? ~ Cicashis The anizal circrincnt perfor-ed by Dr. Ovxanoto involved “3 use af sctlerctive stiroatiwa ca rabbits. In the lfver certain ¢.sineration width necrosis was observed around the lobules end I rocall s07@ morpholosical changes at the sams tins along with cell infiltra- tion near tha Glissonts sheath. I thought if such conditions were pro- lonzed they would develop into rather serious hepatie dysfunction. tris reasen I find the expirizcnt very valuable. For Of course, consider~ a\le dojenevetion was observed in the lymsh:ztic systea of tho spleen, the kidney, end tho intestines, together with hsaatopoietie dysfunction in tha marrew, ete. _™ I shceuld lika to add that ewsycete3 wore fovnd in sputua taken .vle Mr. \woaltve. In urine sa-ples te found espergillus. Missoscople exanination of the limes shoved suppurative pneuzonia olxed «ith .ysolia of asporzillus mostly in the center of the alveoli. It 4s ovfa to sty that some mycelia broke doun the walls of the blocdvessels ard songz penotrated the walls. But this occurred toward tho end, and it bis been noted in the litcreture that asporcillosis is -15- US DOE ARCHIVES 4