7 Hematological Effects on Heavily Irradiated Japanese Fisherme ‘se to each person differed dehis cabin. “To was inferred as about 20 to ity in the thyroid region during « found in the urine samples " The radioactivity decreased con the activity in the urine was rom the fatal case showed that :her, when compared with the Niuera et al, 1956), Sr content in the urine of the the same time the results cf vrence between fishermen and HEMATOLOGICAL OBSERVATIONS 1, Leukocytes The total number of leukocytes decreased gradually, showing minimum counts at about the 4th to 8th week after the exposure. Five cases revealed a count of Jess than 2,000'’mm2, 13 less than 3,000, and 3 less than 4,000.) In one case, the leukocyte level was depressed to 800. A correlation was found between these minimum counts and the doses of individual cxternal irradiation. Similar relationsmp was found beiween minimum counts of neutrophils and the dose as shown in Figure 2. 2 = lay an impotant role in earl y - EARLY STAGE 4ns in the early stage. 3 1500}— 3 Fig. 2. Correlation between the estimated doses to the whole body and the minimal number of neutrophils. *e = 1900}—--—_—*** *e 500 dose of lst day mee * o.--— -— eo * . ° ce ° 70 130 190 250 310 370 430 490 R dose during 2weeks 160 200 300 400 $00 600 700 800 R In most cases a shift to the left of the neutrophils was observed. Staff cells increased in early stage and then gradually decreased. However, in same cases. metamyelocytes and myelocytes appeared in peripheral blood especially with the begin of recovery. In a fatal case who died of liver damage, a considerable number of juvenile neutrophils were observed at the end stage. Lymphopenia was noted between the 2nd and 8th week in all cases. Leukocyte count began to increase after the 8th week. In manycases eosinophilia was remarkable, especially with the indication cf recovery. Eosinophilia continued in somecases for several years without proof of parasites, and one case still revealed slight eosinophilia in the 1968 survey. 2. Erythrocytes At the time of hospitalization a few patients were anemic. was observed in themat the critical stage. No reticulocyte Color index was higher than1. 0. The Price-Jones curves of erythrocyte diameter were displaced to the right of normal at first, and returned to almost normal after one year. These changes corrscponded to changes of erythroblast diameters in bone marrow. 3. Fig. 1 Symptons und signs in the early stage. Platelets, ete. Platelet counts decreased, reaching a minimum in the 4th to 7th week. Most of the fishermen revealed the values below 100,000/mm?. The results of other tests related to hemorrhage showed depression at the critical stage in general and recovered by the 10th week. 4. Comparison with Other Irradiated Cases When these blood changes are compared with the changes of other irraciated