70
Hematological
T. KUMATORI
Table 2 Chromosome abnormalities in peripheral lymphocytes of the fishermen,
data from 1965 to 1967.
72-h culture:
Cases
No. of
cases
examined
No. of
cells
analyzed
Aneuploid
cells °%
Control
10
693
2. 88
Fishermen
1965
Fishermen
1966
Fishermen
13
881
2.05
15
1102
2.90
16
1248
2. 48
1967
Stable
cells %
(;)*
unstable
cells %
(/\*
0. 14
10
750
2. 27
Fishermen
12
950
2.00
1966
1967
al abnor!
re ob
and morphologic
©
Were
ry
ve
co
re
of
tions
generatto
first signs of re
g !
posure
bs
in
with Follow
0.14
(1 10)
(1/10)
2. 28
(9/13)
3.45
(14/15)
2. 88
0. 46
(3/13)
0. 45
(5:15)
0. 56
(15 16)
(6/16)
48-h culture:
Fishermen
E
1. 20
0. 67
(6:10)
(4/16)
(9'12)
(6/12)
2.11
0.74
* Number of cases showing the abnormal cells per total number of cases examined.
l
The hematologica
rted wi
1954 were repo
ng
eaki
Cenerally sp
r the ac
dose soon afte
d
be deci
sons should
this pe
findings. From
y
e therap
to decide th
pan
As to the Ja
t
necessary to detect
ato
observed in hem
so high (Table 2).
2. Unstable abnormalities such as dicentries, etc. were observed (Table 2).
3. The frequency of stable abnormalities was remarkably higher than
in controls (Table 2).
4.
The detailed analysis of stable cells revealed that stable abnormalities
were divided following 3 types:
a, stable cells with balanced chromosome constitution ...67 per cent
b. stable cells with deletion of a chromosome...29 per cent
c. stable cells with excessive chromosome material...4 per cent
5. In 3 cases small chromosomes which are similar to the Ph! chromosome were found.
6. The examined fishermen wereclassified in3 groups according to the
degree of the injuries indicated by the minimum values of neutrophils
shown shortly after the exposure. It was found that the mean values ofstable
and of unstable cells were higher in proportion to the extent of the initial
damage. Minimum values of neutrophils roughly corresponded to the estimated external radiation close.
7.
Chromosome abnormalities in bone marrow were observedin 5 cases,
All of these abnormalities were limited to stable abnormalities.
While stable
cells in the peripheral lymphocytes showed various karyotypes of their own,
these in the bone marrow were limited to only a few karyotypes.
-
SPERMATOGENESIS
As a generative tissue, spermatogenesis has many similarities with hematopoiesis. Therefore, the changes of number of spermatozoa is describedfor
reference. The number of spermatozoa decreased, and minimum numbers were
obtained in 16 cases about 8 months after the exposure. Lowering of mobility
533): ¢
AMANO, S- (19
u Shi
ts
ju
ku
Ga
A. §
ANDREWS, G.
c
Diagnosis an
,
on
Organizati
P.,
CRONKITE, E.
Jonizing Rad
Washington,
a
CGuskova; A.K.
Conference
New York.
jHASTERLIK, R.
Conference
New York.
HEMPELMAN, L
Medicine, -
an
ISHIHARA, T.
a
T.
[SHIHARA
North Ho
a
ISHIHARA, T.
942.
AMMET, H.P.
World tI.
.
KIKUCHI, Tt
stitute £
KIMURA, K.,
Influenc
the Pro
z