Crown
Hematological Effects on Heavily Irradiated Japanese fisermen
xPosed by
tov ar
Teactor ac
al. 1956
os me
; TAsrer
ANDREWs
ct al, Ig
Vearly
1
Tevealed
the miMima]
in :
3
ticalwee
on
st
Nn
j severe
Cases, wWhj
oe 2
reticulum
cellsS. Fj
Figure
ven
Comparing
°
100,
>
..
With nor:
rma‘1
Gmantrs
eTtcal
stage
= 20] (weeks
gr
YB
anf
a 0
og ¢
= 59
E 394
l year
contrcl
3 20
Leukocytes of Bikini patients
(J) (cumulative).
*
6 years
2 aol
Fig. 4
69
0
ve
ro
,
_,
12345 6 7 £ $ id331213
leukce,tes < 107
*
x 103
12]-
a,
>
ee
.
7 a
;
—
7-3
:
é
.
”
-~
Ne
steht
.
wT
Nee
.
or,"
*
”
° “ed.
~
“o.
“Ag,
a!
.
+
e
“dee
ic fice
S at Sth Week.
ot
i
Marrow
y4
Complete
8 not apPl
astsi;
at the
33)
> Bt
8 7
critica} St
age °
a6
—
igi! MOS AGN
mal] Persons.
ay Wat
eMarkah)
.
7 in
nor ys After one
TAR
:
Fig. 5
.
Changes in the numberof leuko-
Ss
= 4
cytes, neutrophils and lymphocytes.
3
i)
=
_
.
wn, ZY
i
07 147 23426070 6
123.456 78 S10 12131415
days
months
years
time after exposure
of normal Japanese. In the case of erythrocytes, 2 years after the exposure,
the curve approximately came back to normal. A similar tendency is seen
in the cumulative distribution curves of platelets.
However, in a few cases slight neutropenia is still observed. Figure 5 shows
the changes of total leukocytes, neutrophils, and lymphocytes of 2 cases which
are representative for severe injury.
A small increase of “mitotically connected abnormalities”, i. e. karyomeres
of erythroblasts, were observed in bone marrow smears of a [ew cases after
10 years.
Cytogenetical studies have been performed since several years. The
results are summarized as follows (IsHizana and Kumatoni 1965; 1967; 1969).
I. The frequency of aneuploid cells was 2~3 per cent, which was not