tiate that
t
=
=
laisini
to nolaaeat®«edd Yo 3 omi3 wns Je noijnaist1 “hod ytonw
time post onset: of:uptake, days,
d
instantaneous fraction of atoms decaying per unit time, day”
a
p?
initial atom ingestjon rate, “atoms day~!,
tf
instantaneous fraction of atoms removed from compartment. i by
ated
a
- ames
dads
-7
am
physiological mechaniems, day™‘,
db
Vdivilvan
eooune dun deni
fe
compartment i deposition fraction,
the number, of atéus ’in “compartment ‘i‘ gelat¢ive.to the number in all
is
|
compartments atthe onset of declining continuous uptake, (c#0),
pes
PP
BA
8
SETCOS tha tote wy!
instantaneous urine activity concentration, Bq 2™*,
:
subject urine excretion rate, & day”*,
ia
wes
et Dana
~~]
.
‘
VGalb
at
fraction fromGl; gest .to bloods; 4+..4,,
oo,
"
ee Gh |
fraction excreted by the urine pathway,
/
wt
instantaneous fraction of atoms removed or added to the atom uptale
*
tao
Ted 1G
per unit time, day” 1 due to ‘ factors"o ther’ than’” padiogeive |‘decay,
:
wit
i
at "EMA
instantaneous body burden, Ba,
o
itt
wn
sit
body burden at the onset of uptake, Bay
eng
‘
yet
3
idgt
elit sh
a
ara
4
i
the number of disintegrations in all compartments occurring durin,
the uptake interval, Bq days.
The development of Eqs. (1), (2), and (3) wae based on the following ciivolution integral.
At some variable time, T, defined during « fixed uptake
interval, T, the daily activity ingestion rate crossing the gastrointestinal
tract to blood is given by
Af P
o
e
-(kgtA)t
.
eo
i
“
fre