HEMATOLOGIC 47 OBSERVATIONS Table 4.1—Hematological Results, Marshallese Control: Groups NO. OF INDIVIDUALS | AGE <5 6-10 11-15 W-2000 16-20 21-30 31-40 41-50 > 50 WEC NEUTROPHILE LYMPHOCYTE PLATELET : Grove AtGrovup Bi Group A | Group B /Grove A|Grove BlGrovur AlGrovur BI Group A M F M F | M F M F M F M F M F M EF q F 10 6 1 14 4 9 4 3 Leeeee & 3 17 10 4 9 3 12 10 (4 2 , | 7 | 13.9 12.8) 6/118 96) 4 | celle ee eee 10.8 89) 3 Bo) lle 5 7 8.9106) 2 4 7.9 93) 8° 2 7.5 94/ 7 8 9110.2) 12.2 88/43 48/64 128 9.3/5.5 39/66 6615.0 4.3 51/43 3.9] 42,2 35.9 39.7 38.7 96 93)65.1 46/56 52/47 28/34 3.4) eee eee eee eee ee feet eed eee 7.5 98 | 4.3°5.8/4.3 5.6/3.8 4.2/3.3 3.7 144129138 47/76 7.9/3.3 41162 4.4 89 738/45 47/46 3.0/3.6 40)3.7 3.61 81 93/49 51/49 4659.5 4.2/2.6 3.9 cc 27.6 43.3 23.6 34.2 295.0 39.2 21.3 35.4 30.2 32.2 eee) eee sex dependency of these endpoints are comparable to that in published data (9.10), with the exceptionof the platelets, on which previous comparable data were not available. Total leukocyte, neutrophile, lymphocyte, monocyte, platelet and eosinophile counts for the several exposure groups are given by day, by sex and age in Tables 4.2 to 4.5. The total white count, neutrophile, lymphoctyte and 40/84 52/51 neeeee wneeee 4.31 eee ee 28.0 38.3 HEMATOCRIT Grove B| M F Group A M F Group B M F 35.0 31.7 35.0 36,2) 38.5 37.4 41,2 39.2 35.9 37.8 38.5 37.7 Flee 37.0 32.6 25.4 20.3 26.5 30.0} 27.4 23.5 25.3 27.6 elle. 48.4 38.7 46.9 38.9 47.2 41,2 42.3 41.8 43.7 41.7 24.5 33.7 42.0 42.3 38.0 39,2 eee ee. 42.3 38.2 46.2 40.1 46.0 42.5 44.1 42.0 40.6 41.0 Hematological Findings, Group I. gelap Ron- The absolute neutrophile count of both the younger and older age groups fell during the second week to a value approximately 70 to 80 percent of that of the controls (see Fig. 4.1). *In Group IV the cumulative distribution curve for platelet counts only is presented Since hematological determinations in this group were not nade during the 39 fo 51 day period, used for leukocyte comparisons among the other groups. -AGES<5 ANO>S of? - b NEUTROPHILES x 10° platelet counts at the times of maximum depres- sion (averaged over the time during which counts were consistently the lowest) are shown in Tables 4.6 and 4.7 for each individual in Groups I and II respectively. Hematocrits for all exposure groups are shown in Table 4.8. Hematological findings as a function of time and age are shownalso in Figures 4.1 to 4.8. The cumulative distribution curves for the various exposure groups, using the average of counts obtained over the period of maximum depression (days 39 to 51 for leukocytes; days 26 to 30 for platelets) are shown in Figures 4.9 to 4.12.* In the figures emphasis is placed on the separate blood elements rather than on the total leukocyte count, since the componentelements have distinct and different time trends after irradiation. <5 (13) POST EXPOSURE DAY FIGURE 4.1.—Serial changes in neutrophile counts of Group I (Rongelap) for those less than 5 years and greater than 5 years of age. Following the depression of the total neutrophile count. during the 2nd week, the values were unstable until the 5th week. At this time the beginning of a second drop (p<0.01) was noted for both age groups, and a low value of approximately 50 percent of controls was