47
HEMATOLOGIC OBSERVATIONS
Table 4.1—Hematological Results, Marshallese Control Groups
| No. OF INDIVIDUALS |
|
16-20
21-30
31-40
41-50
>50
|
| 10 14;
|;
§&
4 !
|
4
3
| ee
|
=
5
«17
4
3
10
3
«10
9
12
4
NEUTROPHILE
LYMPHOCYTE
PLATELET
HEMATOCRIT
Group B [Groce AiGroup BiGrovep A/Groue_ B) Grove A
M F
M F
M F
M F
M F
M F
Grover B:
M F
Group A
M F
Grovur B
M
F
9
7;
13.9128]
12.2 88/43 48/64 40/84 66/50 43] 42.2 35.9
4
67118 96/128 93/55 39/66 52/51 54)43 3.9 39.7 38.7
2
4
cette
eee eee
feet ee
eee eee
eeeeee
renee
28.0 38.3
eee
10,8 8.9)
96 839] 51 46156 62/47 3B] 34 24) ee
35.0 31.7
35.0 36.2
24.5 33.7
lee fo
38.5 37.4
41.2 39.2
42.0 42.3
eee |
35.9 37.8
38.5 37.7
38.0 39.2
pe eleeee
46.9
47,2
42.3
43.7
46.2
46.0
44.1
40.6
3
5
2
8°
7
5B
7
4
2
8
eeeeeee
8.9106]
7.9 93)
7.5 9.4)
9110.2}
Penne eee
eee
7.5 98/43
14.412.9/3.8
89 7.91/45
81 9939/49
eee
eeeeee
58/43 5.6/3.8
4.7/7.6 7.9]/3.3
47/46 320/36
51/49 4.6/3.5
sex dependency of these endpoints are comparable to that in published data (9.10), with
the exceptionof the platelets, on which previous
comparable data were not available.
Total leukocyte, neutrophile, lymphocyte,
monocyte, platelet and eosinophile counts for
the several exposure groups are given by day,
by sex and age in Tables 4.2 to 4.5. The total
white count, neutrophile, lymphoctyte and
platelet counts at the times of maximumdepression {averaged over the time during which
counts were consistently the lowest) are shown
in Tables 4.6 and 4.7 for each individual in
Grroups I and II respectively. Hematocrits for
all exposure groups are shown in Table 4.8.
Hematological findings as a function of time
and age are shownalso in Figures 4.1 to 4.8.
The cumulative distribution curves for the
various eXposure groups, using the average of
counts obtained over the period of maximum
depression (days 39 to 51 for leukocytes; days
26 to 30 for platelets) are shown in Figures 4.9
to £.12.* In the figures emphasis is placed on
the separate blood elements rather than on the
total leukocyte count, since the componentelements have distinct and different time trends
after irradiation.
*In Group IV the cumulative distribution curve for
platelet counts only is presented since hematological
determinations in this group were not made during the
39 to 51 day period, used for leukocyte comparisons
among the other groups.
4.31
eee eee
4.2/3.3 3.7
4.1162 4.4
40)43.7 3.6]
42/26 3.9]
27.6 43.3
23.6
25.0
21.3
30.2
34.2
39.2
35.4
32.2
37.0 32.6
25.4
26.5
27.4
25.3
20.3
30.0
23.5
27.61
48.4 38.7
38.9
41.2
41,8
41.7
42.3 38.2
401
42.5
42.0
41.0
Hematological Findings, Group I. Rongelap
The absolute neutrophile count of both the
younger and older age groups fell during the
second week to a value approximately 70 to 80
percent of that of the controls (see Fig. 4.1).
<5 (13)
nm
<5
6-10
11-15
M-9
Grove A!Grovup B Group A
| M F 3
F
M F
|
i
NEUTROPHILES x 10°
Ace
WBC
POST EXPOSURE O4Y
Figure 4.1.—Serial changes in neutrophile counts of
Group I (Rongelap) for those less than 5 years and
greater than 5 years of age.
Following the depression of the total neutrophile count during the 2nd week, the values
were unstable until the 5th week. At this time
the beginning of a second drop (p<0.01) was
noted for both age groups, and a low value of
approximately 50 percent of controls was