CLINICAL OBSERVATIONS AND TREATMENT gitis with prominent lymphoid follicles, fever of 99-100° F. during thefirst day. and a puruJent nasal and tracheal discharge for about 10 days. It was of interest to determine whether the appearance of URI could be correlated with the dose of radiation received or with changes in the leukocyte count. Fifty-eight percent of the individuals in Group I and 56 percent of the individuals in Group IT developed URI. Seventy percent of the affected individuals developed symptoms between the 27th and 32nd post-exposure days, and the others developed symptomsin the subsequent 2 weeks. Fifty-seven percent of the affected individuals were observed to have an upward trend in their leukocyte counts, the increase being due primarily to granulocytes, Since an increase in the mean granulocyte count of the entire population occurred about the 29th postexposure day, it seemed pertinent to determine whether in individual instances the increase was related to the presence of respiratory infection. The relationship between the observed leukocyte merease and the presence or absence of upper respiratory symptoms in Groups I and IT is shown in Table 2.2. Seven of the 27 individuals that developed both URI and a leukocyte increase developed the leukocyte increase 3 or more days before symptoms of URI appeared. It is also of interest that the medical personne] involved in the care and study of the radiated individuals had an equal incidence and 21 Table 2.2—-URI and Changes in Granulocytes in Groups I and II NUMBER oF INDI- VIDUALS URI; rise in granulocytes___-.-------URI; no rise in granulocytes_-_-_------No URI; rise in granulocytes.-_---_---- No URI; no rise in granulocytes_------ 27 20 16 19° severity of respiratory infections. The incidence and severity of respiratory infection in Group IV, which had received only slight radia- tion, was the same as that in Group I and II. The appearance of URI, therefore, did not appear to be related to the dose of radiation or to changes in leukocyte level. 2.5 Comparison of Diseases Seen in Groups I and II With Those in Group IV Tur Diseases THat were seen during the pe- riod of observation of Group I and II, which were exposed to the highest doses of radiation, are listed in Table 2.3. None of the diseases appeared to be related to the effects of irradiation, either directly or as a result of hematologic disturbances. For comparison, the diseases that were seen during the period of observation of Group IV, which received the lowest dose of Table 2.3—-Diseases That Were Observed in Groups I and II NUMBER oF INDI- DISEASE VIDUALS Furunele._._--.---- 22-2 wane nee Gum Abscess__.______._.--------.-----Cholecystitis_._.-__._.-.---_--.- ae Tinea__.-_-_-------------------------Mittelschmerz___..___2:..--------.----.Generalized urticaria___._____.-_._.-___Erythema multiforme___._-_.__-_-----_Migraine headache_..__.____-__-____.___- | | 2 1 1 1 1 1 1 1 DISEASE Bronchitis. __--.---.- -- wee ee eee eee eee Aphthous ulcer of tongue___-------------Spondylolisthesis - ___-- woe ene e eee eee Impetigo----_-----_-----.-------------Tooth extractions. -.._._._-------------Gastroenteritis. ______ Ween e eee e eee Upper respiratory infections. __.___-_----Follicular tonsillitis............--.------- NUMBER oF INDIVIDUALS 1 1 1 5 2 10 47 1