SUMMARY REPORT
yor
RESEARCH PROJECT AT (30-1)-1243
seaass
1 August 1951 to 1 June 1971
ee
5 tiie
SUEMITTED 30 June 1971
3 if 3 iZ
TITLE OF INVESTIGATION
apie
A Study of the Physiological Functionand
Has LE
Radioactive Iodine
hae
i i
3 i : Ut
3
a : 2] i
ii i FE
5
2a
ashi
407557
Histological Changes_in Thyroids Irradiated with
PRINCIPAL INVESTIGATOR
Grown M. Dobyns, M.D., Ph. D.
Professor of Surgery, Case Western Reserve Universi
INSTITUTION
Case Western Reserve University School of Medicine
at Cleveland Metropolitan General Hospital
This has_been a broad investigation of physiological and :“ppholog]
produced by 1317 in the thyroids of animals and man. Tre work <7
1949 under an AEC contract at the Massachusetts General Hospital, Bosto
under that contract. In 1951 the principal investigator moved to Case
' University where the present contract began.
charges
began =2
_Tthe
Weste=zn Reserve:
Various types of observations have been in progress at the same
to the variability and availability of special clinical opportunities
te the use of 1317, owing to the necessary time intervals between
observations on animals and in man, and owing to acute demands on re
when unique opportunities arose, efforts have been directed in diff
depending on the circumstances that existed. The personnel engaged in
continually occupied with different aspects of the project depending on
of circumstances. Indeed, the collection of material from irradiated
and the study of these individuals has extended over many years in
to collect
enough data to permit satisfactory conclusions. We mist be contimually fooled wp to
go into detailed study each time an opportunity arises, but remain occupfed with cther
more elective animal studies when circumstances are not pressing.
The study of the morphologic changes grew out of the first observations on ah,
treated thyroids in man. A good many years were spent developing vari
methods of
t a te
column and paper chromatography for the separation of iodinated compo
when these methods were not available. These methods were used to stuity
changes in the amounts of these compounds in blood and in thyroid tissue]in normal anc
irradiated thyroids. Extensive and detailed observations were made by
on selected patients at the time of 151I therapy, and the information
reference as follow-up information was cbtained on these individuals
th