TT RI ; Cronxiry et Cases, Hematological Effects on Heavily Irradiated Japanese Fistemmen omparit ng 69 by reactor ac. al, 1956 100 Fig. 4 witb h ann orm aa2l 80 voters L year ’ 6years & Nd cases exposed cumulative percent Sa - contral Leukocytes of Bikini patients (J) (cumulative). 345 67 6 9 10tl1215 leukocytes x 108 ao — T-3 ; : - leukocytes ; - sos Le a e ahr “ne. . o . re : “ay e mh) HS mB. : own “<2 ee S at Sth week e : WiIth the begi Plastic an d th n t urne m Ove e,t Was not Compl d an em ete Was not aplastic the critica} Stage . i ie nuclea Phils toxic r debris of g @ulation s ce abnorma litieg o f ° maarhably e . After 20rmal pe o5ne rson a a=: 2 ‘ e Pa2 re & ON an an . ‘on Curve s of leuk o. © the Jefe of the z= = : 2 hey Xamined ~ lymphocytes Wse erryed, neutrophils -_ “ HNWEUHYSBOOS Tv “e. rree KG HMNwWRUDWO OS .~ HN WED UOWO s Fig. 5 Changes in the number of leuko- cytes, neutrophils and lymphocytes. + G7 142) 354249% 69700 ar 6 : 123.456 78 91011 12131415 years time after exposure of normal Japanese. In the case of erythrocytes, 2 years after the expusure, the curve approximately came back’ to normal. A similar tendency is seen in the cumulative distribution curves of platelets. However, in a few cases slight neutropenia is still observed. Figure 5 shows the changesof total leukocytes, neutrophils, and lymphocytes of 2 cases which are representative for severe injury. A small increase of ‘‘mitotically connected abnormalities”, i. e. karyomeres of erythroblasts, were observed in bone marrow smears of a few cases alter 10 years. Cytogenetical studies have been performed since several years. The results are summarized as follows (IsHiHARA and Kumatont 1965; 1967; 1969). 1. The frequency of aneuploid cells was 2~3 per cent, which was not