frozen at -b5°C and transported in this state to the Army Medical Conter for enzyme system studics. NCI** ; Responsible Agoncy: National Cancer Institute n radiatio bomb atom the of effects the study To e: Objectiv of on the hematopoictic system, on longevity, 45 a source ; genetic effect, and as a carcinogenic agent for mice, Procedure: Animals would be exposed as in 3,2.1.1 at distonces Whore sublethal doses could be expected, Long term follow-up, and breeding studies would then be conducted after roturning the animals to the National Cancer Institute. Project 3: 3.2.3e0l Responsible Objective: area burned Procedure: Study of Thermal Injury Agency: National Military Establishment To study the relation of the mortality to surface and to the degree of the burn. An attempt will bo made by suitably timed shiolds EoBoparate the majority of the thermal exposure from the donizing radiation exposures Suitably shielded pigs will be placed whero burns of varying severity can be anticipated, The influence of the burn on mortality, and as a complication of rediation injury will be studied, Baleded Responsible Agency: University of Rochester Objcctive: To compare atom bomb flash burn with material from Bikini, and with flash burns produced in the laboratory) Procedure: Suitably shiclded pigs will be placed where burns of varying severity can be anticipateds The histological character of the burns, end related phenomena will be studied in an attempt to evelunte other atom bomb flash burns, and leboratory flash burnss Bele ded Responsible Agency: Argonne National Laboratory Objectiver To analyze histologic chinges in the skin of pigs oxpesed to thermal radiation, for comparison with the findings in the skin Procedure} from blast, radiatiom returned to of the victims of the Los Almos accident, Young pigs would be oxposed, suitably shiclded and by timing devices from some of the ionizing Specimens of skin would be removed,fixed and the Us. Sy for study. Project 4: 3620 aed Study of Blast Injury Responsible jigeney: National Military Establishment Objective: To study blast injury using improved containers basedonoxpericnce at Inyokorn and Bikini,’ Thoro wore serious discrepancies at Bikini betwcen the degree of injury and the estimated overpressurc, with lethal effects from peak pressures that are not lethal with H.E, ~ 4 . Further study of this is desired, Procedure: Small animals, shiclded from thermal radiation would be exposed in various » citions related to blast measuring devices, They would be sacrificed as soon as recovered Baar a4. te Awe *¥* Proposal submitted too lete for action by Committee HOO nab G2 48 TPTTUTTI systems is Knowledge of pattern of change of tissue enzyme ; . sought. bo quick will 2 3.2.4e in as ed obtain s Tissue ure: Proced re 3.2.4.4 cont'd