e wer @ 4 » Biologioal Test Progran for J ~ Division, LiL A. Objective: The fimiansntal objective of the biological program ia to teovice inforaation which ean be used in planning effective medical care for the victims of atomic mrfare, and for the viotina of iniuotrial scoofdents in nuclear enerzy plants. Such planning must necessarily depond on radiobiclocical staxifea which utilige the unijue radiation of the atomic explos= fon, A satisfactory Mologieal test program should provide data whieh can permit evaluation of atom bomb r-diation injury in terms of the injurious action of roontgen, garma ani neutron rediations of e character that cen be produced by conventional seans in the laboratory, idequate medical plamming oan not be anticipated util it is possible to trans- late laboratory comiitions to field conditiams with a high degree of certainty. B. Programiwhich has been approved by the Division of Sialoc:y and ciede icine, Atawie inergy Comission, and J-Division, Los Alamos Seferntifie Laboratory: 1,0 Gol This project will provide an adequate muuber of or use at shot timo. These animals will have beon born and reared on Japtan islani, ami should thon be acclimatized to to the total local cnvironment. perforaed prics to the shots, uitable control studies will be The response of the animls will te tested with 260 KV 2ray after residence in the tropics, The plan should provide the following nv:bere of animals for the testa: 12,000 mica of IAW, strain; 120 .nerican fox terrier dogs; and 280 Daroe *hairless' pics. “ee 2.0 af acute radiation in Thess studies will form a basis oF a cczparigon ological response to short-buret redifetion from the atom bomb with the response to ionizing radiation delivered at conventional rates, 2.1 Study of acute lethality, Likg, and survivial versus dose ami 4istance. (all species) 2e2 Study of histologie changes in tiesuse obtained by serial sacrifice after exposure. (all species} 25 Stuty of histochemigal ahanges in tissuca, as in 202. 2e% Stuly of chanes in enzyme systems in tissues, as in 2.2 2e Study of pr-tective agents on Lian. (mice) 2.6 Study of effect of atom bomb radiation on longevity and caroinogensis in survivors. (mice) wee ‘ 7 w #el@é 4centt =