ACL TL
KAULATION
SioekGibS
Lob.
Hedical Departwent
AW Thbhik
MAnAGLS EX
Cronsite
Brouvkhaveu watioual Laboratory
Upton, hew tork
11973
ABSTKACT
Radiation synadcrowes produced by large doses of
into
three general wroups depending on dose of
time after exposure.
appeacs in minutes
appears after doses
The CNS syndrome
to hours, and kills witila hours
of a tew hundred
nausea, vomiting, diarrhea,
to 2000 rad.
thousands of
cto days.
It
rad,
The GIS
is charactertzed by
and disturbances of water and electrolyte
It nas a high wortaltty in
the
firse week after exposure.
wes
ge
cose Sarme
we tht
aie
*
Sah
: re :
es
-
‘
metabolism.
reguires many
cadiation and
Se eeeen Sena
ace divided
ionizing radiation
Survivors will
then expertence
Vependiag on dose,
therapy.
the HS as a
result of marrow aplasia.
survival 13 possible with antlbioctic and
The relattonsntp of graqaulecyte depression
and huian betngs is Lllusteated.,
aurtality of
The rule of depth duse pattern un
why alr exposure doses sway be misleading.
molecular regulators.
transplants
to mortality in do.,s
radtatlon exposure is described and used as
ts descelded based on antibfotics,
teansfusion
an indication of
The therapy of cadilation injury
transfuston
therapy,
aad use of
The limited role of matched allogenic bone arrow
is discussed.
Tnis ceseuarch waS supported by the L.S. Department of kLnerey under Contract
vE~ACO2Z~76CHOUOL6,
Accordingly, the U.S. Covernwent retains 4 nonexclusive,
royalty-free license to publish or reproduce tie publishea for. of tils
contribution, or allow others to do so, for U.S. Governnent purposes,
50129491
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