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Cyt
tate
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et eh oe an,en ie
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Hematopoietic Molecular Regulators in the hanagement ot the Lone
Marrow hypoplasia
In the last ten years several molecular regulators of hematopoiesis
have been identified, purified,
sequenced, and by recombinant DNA
techniques are” being produced in large amounts,
These are interleukin-1
and 3, granulocyte- macrophage colony-stimulating factor, macrophage
colony-stimulating factor, granulocyte colony-stimulating factor,
endothelial celis, and fibroblasts
produce granulocyte-macrophage colony- stimulating factor.
accelerates
to
The latter
the production of granulocytes and macrophayes
izole
upon in vivo administration produces a granulocytosis with accelerated
setrum ~
production of granulocytes.
funcetiunal granulocytes
colony~stimulating factor accelerates
in vitro the procuction of
granulocytes in colonies and in vivo accelerates
granulocytes and improves
(50-55).
mouse
4-5 times
ry
ae
ap Ee
aaNet ee
rid
has
‘it
heh
OLere
Vs
to
near
48 hours before,
administered
" ae
ay “rT
trradiation,
100%
IL~]
survival.
When
the normal
to primates aud mice
four
GN-CSF and G-CSF
to produce a
level as long as
by radiation or chemicals and
100% lethal gose of radiation
administered
it is ineffective (50).
to primates and shown
been given
(51-54).
turns a near
hours
before
have been
sustainea granulocytosis
the materials are administered.
in which
or
the marrow has
the granulocyte counts are
of
It
been suppressed
increased
Erythropoietin has been shown to be of sajor benefit in
Stimulating the production of
red cells
as a result of renal failure (55).
combinations will
in
individuals with severe anemia
It its assumed that these avents or
be of potential benetit in
tne
with bone marrow Suppression as a result of whole
other hand,
it
is conceivable
that forcing cells
body
trradfation.
into mitosis
On
the
before DNA is
repaired may fix genetic
failure of
the mitotic capacity of pluripotent stem cells or an earlier and
incidence of leukemia.
result
individuals
adequately
increased
injury and
treatment of
in either an early
These are possibilities
that need
to
be
_ &xplored experimentally.
a,
|
to
hen administered 20
a
in an 2
the
bacterial-killing capacities
IL-l has been used as a radloprotector.
hours prior
in
the phagocytic and
the production of
-109-
sor
at
ee
“0 keep |
Granulocyte
ek
y
ec
the effectiveness of the
in phagocytosis and bacterial killing.
1 es
ADS.
It also increases
ae
in vitro and
ee,
See
ie
Lerman es
stimulates T-cells,
we
. eoTe,whan v4.
Whale
. . i,oer
eteoe Mie ma de ee eo
macrophages,
=.
a3
with
Interleukin-1], a product primarily of activated monocyte or
PE aE cos ta atelePale aha ry
rt
erythropoilein.
and
BAGeSeeeas xe
tion
a
* ye
ro
a”
_
_7
Per
2 a
nat
.
Cea
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eM
tt em
ete
soe