32
Tabie 18
Correlation of Immunoelectrophoretic and Peripheral Blood Findings
With Age and Radiation Exposure!} (D =decrease,; [ = increase)
Unexposed group
Exposed group
Change
Correlation
Percentdif.
Significance
with age
with age (r value)
from unexposed
(p value)
Lymphocyte transformation
BD
0.89
Serum proteins
Total serum proteins
Albumen
I
D
I
I
Criterion
Total globulins
Alpha-!
Alpha-2
Beta
I
A (IgA)
I
M (IgM)
G (IgG)
Kappalight chains.
Lambda tight chains
K/L ratio
I
I
I
I
I
D (IgD)
Blood findings
Hematocrit
Sedimentation rate
Total leukocytes
Lymphocytes
Neutrophils
Platelets
0.68
35
245
— 15
+ 15.0
2+
O1
37
43
—31.0
— 20.0
Ol
01
+ 18.3
01
49
—17.0
05
.20
78
.96
24
41
—
~—
—
—
+
74
22,
69
AS
4
—17.1
.32
I
Immunoglobulins
11
38
I
Gamma
—
75
— 6.0
,
— 3.0
O1
.03
I
20
D
I
D
D
I
47
72
43
91
44
+ 2.9
+11.4
— 2.5
— 0.1
—13.8
07
08
39
1
.O+
D
65
— 84
.O4
4.0
8.0
3.0
14.0
0.4
98
Table 19
Serum Proteins, 1973-1974
Group
Total protein
Albumen
Alpha |!
Alpha 2
Beta
Gamma
Total globulin
Rongelap
Ailingnae
Utirik
Unexposed
7.760.70
7.99+0.51
7.60+0.50
7.60+0.71
4,.29+0.50
4.307+0.37
4.290+0.43
411+0.45
0.20+0.05
0.19+0.07
0.160.06
0.19+0.06
0.692-0.12
0.720.15
0.69 +-0.30
0.75+0.14
1.082-0.24
1.050.20
0.89+0.23
1.00+0.24
1.59*+0.41
1.76+0.38
1.67+0.45
1.57=-0.48
3.5420.58
3.600.356
3,330.50
3.52 0.54
podiploid levels were related also to radiation;
this was more pronouncedin the males, with the
exposed having 2.8 times as many hypodiploid
cells as the unexposed, whereas the exposed femaies had 1.3 times as many as the unexposed.
Polyploid levels were not found to be related to
radiation. Both sex and chromosomesize appeared asfactors possibly related to hypodiploid
levels. In all subjects, regardless of sex or exposure,
the largest and most frequent loss of chromosomes
was in the G(Y) group (2.3 times expectedloss). In
the C(X) group, females lost 15.2% more chromosomes than expected and males 12.6% less. No sex
or radiation effect was apparentin the otherfive
chromosomegroups. A series of additional cultures indicated the presence of chromosomebreakage factor in the plasmaof the exposed subjects. In
cultures of the latter, chromosome aberrations