With thease urvertain cbhservations uncind, a luboratecy experiment sin cost
was cesimmad te tent tha akeve hypothesis. A preun of Th youn fomlie mist ides ciea
to those used in cther radiation exparbacnis woroisenoome cf fourbesaca loveic Lf
131i which were Hace to cause relative ty mild depres Cf thyroid dbmice.
Ter - oth
ware bred to normal sales after ali 124i had disanpeured from th: hard.
litic.
were identifies wiih motherg aml Ledy weights cf iittes inales mendes. Tey nem.
weaned whan appresinately "9 yuma, ted a diat with asequile dat sot Eiztens latins 2 oar
sacrificed at about 256 ses ot Lorty weient. Tho thymids wee cetdpobeus) + diso~st Gut amdoagishedd.,
fomale ccomleois.
Uhtce dare comaarid WEG, mata roa paiterg womb
tocher JlatyL
Mapeatend laittora Clore) werd oltabsed pen tle Boate: fo. acs
co
A paride i of ame cya crount il
theism sermwsmtive
calaeiditieau woavedb
Ties
te
oo est
that visaprias i.on the fanerled of the fuente three ea liatien dose Mbesls Clupa ee
inereasiss, Uvyreid weichta hut tha obfreriss feud chs feurth oad sob heavy pean
Somlics had thyrci: weight witen moé: naarly reserbied nertal conmtrpls tsis tht san
Uniurlunately, ti nusber of animalg usest in Ghesea coteutinewit) wdo poral) ad the: ss
haavily middated cotheort wens nat meadily imprestiit hoard todo Glplitier .
fe out.
Of tha maviost scue of radiation, these few ofispring did now fit phe pattem
Gosninely establicned ty the lower lovels of Ue series. These exp
Pepaiied.
The questicn of the adolescent goiters in children of exposed
Marshalicsa on eeneelap «as mr-expleral rere thoreucshly in the mst
With tha previous incesplate cLservations in mi:d, ‘he presences of
adolescents worm alter the fallout exposura was mevicwsd:
in child mn of expose: =
and wmexposced ponuluticn of Penselap, in a street survey of all rec le on Gtirix ivh:
had received very icw level «xposure) and on a population of alrcut Ze on iikier wh.
there: was no fallcut. Thence data on the presence cf diffuse thyrai eslac=smeni are.
and history of purents! exposure are now being, analyvogl. It is cle
Very usu anons tne Harcsnaillese and that when found. such gs cn
often in individuals wtsce origin was half German cr Portuguese.
*
.
THE STUDY OF MORFHOLOGIC CHASES DI I2AN THYPOILS
PREVICUSLY TREATIO WITH 1411
Unfortunately for cur work, in the past yeer no patients who
been treated with 131] cer hycerthyroidica and studied extensively
srevicusl>
m cur perserns_
series hive iid clinical cousen for thyrcid surrfer;, which would fe mit stucy cl hrs
thyroid
tissue.
Oppertunities to cbtain such tissues For study ccciir
fashica end onl; wren a sass develcrs which causes concern.
Marshallese patients who
-
in a rantc=e
There ere, however. the
furnished material of this xind during thefpast
~~
THE RELATICNS:IP CP
-s
Arye
pees
_
oe
wee tae
SIT RPE NUCLEAR FORMS TD THE PERSISTIcr OF
PATIETS TREATIO . CR GRAVES DISEASE ALD FREVICUSLY STUD
Although we nartially nemve er partially destroy the excessiv
thyroid in Graves' disease to correct hyrerthyrcidisn, the untmcwn
Ls
—
yos>
’
a
@rivirg force shnat
makes tie thyroid cveructive trobahly continues fer a time. The requls of <uis
driving force may b2 cerpurubic in some respects to the stimelus shih is cvsaten
aan
des Fae eet He
by givin; antithyroid criss to nerme@l rats.
We knew that antithyro
to mats previcusity treated with 13517 mekes the Sisarre nuclear f
evident. The sresence of bizarre nuclear forms in sare
it treat
and not in others ight 52 attributable to the centirued stimulus o