IF SPECIFIC INFORMATION IS KNOWN REGARDING EXPERIMENTS OR RELEASES, PLEASE COMPLETEITEMS 18-24 18. CATEGORY (CHECK ALL THAT APPLY) BY EXPERIMENT Bl RADIATION [1 RELEASE (1 TOXIC CHEMICAL [0 CONTROLLED SUBSTANCE Special Collections UC San Francisco San Francisco, CA 94143-0840 Accession Number: AR-85-34 19. TITLE OF EXPERIMENT(SVYRELEASE(S) Hematological Effects of Total Body Irradiation; Metabolism and Effects of Radioiodine 20. PRINCIPAL INVESTIGATOR Low-Beer, Alexander, Stone, Miller, Aggeler, Holmes, Dailey, Shetine 21. INVESTIGATOR'S AFFILIATION UCSF 22. DESCRIPTION j Report #1- 7/1/49-4/15/50 Biological Effects of Radiations from External and Internal Sources- States that psychiatric patients from Langley Porter Clinic were used as controls in radioiodine/thyroid tests. Descriptions of a number of experiments using X-rays, radioiodine, and radiophosphorus. There is also a report of thyroid uptake studies that used 1131. | Report #2- 4/1/49-2/28/50 Hematological Effects of lonizing Radiations VI!- This report follows up the hematological studies in the above mentioned report. Gives detailed information on blood counts before andafterirradiation. Report #3- 10/50 Experience at the University of California with the Treatment of Patients with Hyperthyroidism by 1131- This report gives a history of the use of radioiodine, dosages, methods of administration, and results. Report #4- 10/50 The Correlation of the Initial Rate of 1131 Uptake in the Thyroid with the Clinical Evaluation of Thyroid Function1131 uptake research. Report #5- 3/28/52- Hematology Section, Part C Hematological Effects of Total Body Irradiation- Reports of blood counts done on both patients irradiated and normal subjects. Report #5- 3/28/52- Radioiodine Section- 1131 studies on patients with thyroid disorders. Some patients appear to have been given tracers for the purpose of examination upon the removal of their thyroids. Report #6- 1/27/53- Hematology Section- |. Studies of Bone Marrow of Patients with Cancer of the Thyroid Treated with Radioiodine- This reports uses humansirradiated with 1131 as part of their cancer treatment to study the effects of radiation on the blood. Report #6- 1/27/53- Radioiodine Section- These experiments involve research into the uptake of 1131. Report #8, 1953 Annual Report contains documentation (Section 2 of the Hematology Section) of an experimenttitled “The Effect of 1131 on the Bone Marrow" by Paul Aggeler. The experiment's purpose "was to determine the degree and types of changes which occur in bone marrow of patients with carcinoma of the thyroid treated with large, repeated doses of 1131. Somepatients showed severe bone marrow damage. in the course of the investigation, some patients were also studies who subsequently proved not to have carcinoma of the thyroid and were therefore given only tracer or thyroidectomizing doses of 1131." In the Radioiodine Section of the samereport, there is documentation of an experiment on 18 patients with cancerof the thyroid. They were given 1131 as an experimental therapy and observed. Another experimentinvolved the pathologyofirradiated thyroids and a follow-up study of 175 previously irradiated thyroid patients. (See Page 3 for more notes on this series) 23. DATE(S) OF EXPERIMENT(SVRELEASE(S) 24. CONDUCTED BY 25. LOCATION(S) OF EXPERIMENT(SYRELEASE(S) (FACILITY, ORGANIZATION,CITY, STATE) 26. CROSS REFERENCES(TO OTHER RECORDS; EXPERIMENTS) 28 PROVENANCE/RECORDSLIAISON OFFICER Andy Mugnier Lawrence Berkeley Laboratory 29. TELEPHONE 30. MAILSTOP OF PROVENANCE 31. QA REVIEWER 32. TELEPHONE 33. DATE OF REVIEW Archives and Records Office 510-486-5525 [Phone] 510-486-7200 (FAX) 10/12/94 Rev. 6/16/94.