-wo the probabiiity OF lesions of specis. interest is anticizated, a trader of -*1r is given in advance and with autcracicgraphic tecnnisues in operation, the necessary work cn the tissues can begin as socn as the tissue is removed. Althougn we have been intereste= in the primary malignant lesio multiple minute lesicns and the frequency of the “atypical” smail le met yet declared their clinical or ticroscopic malignant potential h Special attention. A very importar.t clinical consideration here is thyroids that are at risk (including the Marsnallese) should be tot iS fo>.2, the ions tnat have Ve cyaen our hetr:er such ly removed. Between 1956 and 1960 when the risk of carcinoma of the thyroid foiiswing radiation to the head and neck became an issue, we had available the reco s <= 200 individuals who had received x-radiaticr. between 1939 and 1949 for tube ulout rzervical lymphadenitis. Of those that were living, sixty of these individual Were sraced and examined for thyroid nodules. There were 12 found to have masses an 10 —mderwent thyroid exploration. Three carcinczes were founc; the remaining w ade-omas. Postmortem records here showed carcinome of the thyroid in another pati tc not_Tperatse One of the several that was considere< an "atypical adenoma" has rec = in the last year and now on reoperation shows microscopic features of carcinoma. Two == the patier.: who originally were found’> have masses have continued to refuse exp oram=on or a recent reexamination by us. These observations have not been publishe ber=ase we have hoped to camplete the observations <. all of the group. The Kinetics cf Various Treatment Doses of 131y (An Adden We have described in previous reports our accumulation of data pattern of 151] iodinated amino acics and free iodide in the serum ) the changing and ur<nme and the disappearance of 1°11 from the thyrcid following treatment doses for] hype-hyroidism. graphy. Through the years we collected detailed data on over 75 Gr patients following the treaunent doses. These quantitative data we B. Brill (Vanderbilt University) whc with his associates had been s in models devised by Berson. These snalyses have then been related ‘the gland, the size of the dose give., the size or the dose lodged finally the features of the clinical response that followed. We have to review and comment on two rough xcanuscripts prepared by Dr. Bril¥ esting results from these studies. Answers to further questions ard manuscripts are being revised. It = hoped that some definitions termining the appropriate dose of 15-1 for given patients and for Outcome by making certain early crivtical measurements. drafts will soon be available for O=ther review. tative chromato- es' =“sease givez to Dr. A. ying this materia: Oo the weight of the zland and ha= sn opportunit. descbing interbeirz sought. The be =sund for deer sedicting the Dr. Brill tdlls == the new The details of some of the mere recent experimental results cor.z=ined in two recently submitted Manuscripts. Cozies are attached. The reader i§ enco=aged to review them because much of their coctent is not included in the pré@gres= re : Photocopies of the illustrations nave been used Dut actual photographs = show detail can be provided. Reprints will be eévailable.