37 Table 21 Kinetic Analysis of '**I Studies Thyroid,” per day Thyroid fraction’ Exposed* 1.10 (0.34-2.57) 0.67 (0.33-1.27) 0.40 (0.25-0.65) Unexposed* 0.81 (0.17-1.99) 0.79 (0.23-1.47) 0.52 (0.26-0.77 ) 2 pre TSH post TSH 1.20 0.80 1.71 1.19 0.41 0.60 20 pre TSH 2.12 2.30 1.81 0.62 64 pre TSH post TSH 1.88 0.81 1.08 1.56 0.36 0.66 3 0.52 0.005 0.01 5 0.86 0.14 0.14 69 (partial thyroidectomy) 1.13 0.15 0.12 33.3 2 (partial thyroidectomy) 1.53 0,92 0.37 20.0 61 (on thyroxine) 1.26 0.58 0.31 29.0 54 0.50 0.69 0.58 65 1.08 0.72 0.40 20.4 59 (on thyroxine) 1.65 0.10 0.06 16.9 42 pre TSH post TSH 1.87 0.69 1.29 1.30 0.41 0.65 61 pre TSH post TSH 0.13 0.50 0.48 1.67 0.78 0.77 0.20 0.97 0.82 Subject No. Location and year Marshalls, March 1965 BNL, June 1965 post TSH Marshalis, March 1966 BNL, June 1966 lodide space, liters Urine,* per day _33 pre TSH post TSH 65 pre TSH 1.10 0.45 1.57 0.49 0.78 post TSH 2.35 1.83 0.82 0.31 59 pre TSH post TSH 3.53 1.29 1.51 3.09 0.30 0.71 114 0.33 “Fraction of extrathyroidal iodide excreted in the urine per day (A.,,,). Fraction of extrathyroidal iodide transferred to the thyroid per day(A,,). “Theoretical thyroid uptake, A.,/(A., +A.,,). ‘Mean and range of 12 subjects. “Meanandrange of 9 subjects. - signs of hypothyroidism: coarse facial features, dry skin, and Achilles’ reflexes with typical sluggish return. There was no palpable thyroid tissue. They did not show apparent mental retardation. TSH levels (Table 20) were markedly elevated in both boys, corroborating tle presence of primary hypo- thyroidism. Figure 28 shows bone age retardation in one of these boys. Typical bone dysgenesis associated with hypothyroidism** was noted in 1965 in these boys. Figure 29 shows such changesin the heads of the humeri in one case (No. 5). From Table 20 indications can be seen thatseveral other children with thyroid abnormalities (subject Nos. 2, 20, 33, and 65), some of whom