67
26. Conn, S.H. eT at., Internal deposition of radionuclides in human beings and animals, in AEC-TID
5358, Chap.5 (see ref. 1).
27. James, R.A. anv Ng, Y.C., UCRL 12273, December
1964 (reproduced in Appendix 2).
28. Ratz, J.E. anp Conarp, R.A., Elevation of serum
protein-bound iodinelevel in inhabitants of Marshall
Islands, Am. J. Med. 40, 883 (1966).
29. Foss, O.P., Hanxes, L.V., ano Van Suyke, D.D., A
study ofthe alkaline ashing method for determination
of protein-boundiodine in serum, Clin. Chim. Acta 5,
301 (1960).
30. Gotton, V.A. anp Prrt-Rivers, R.A., A quantitative
method for the separation of thyroid hormones andrelated compounds from serum and tissues with an
anion-exchangeresin, Biochem. J. 72, 310 (1959).
31. Kypp, D.M., Man, E.B., ano Peters, J.P., Concen-
tration of precipitable iodine in the serum, J. Clin.
Invest. 29, 1033 (1950).
32. Man, E.B., Kypp, D.M., anp Peters, J.P., Butanolextractable iodine of serum, /. Clin. Invest. 30, 531
(1951).
33. Rat, J.E., The role of radioactive iodine in the diagnosis of thyroid disease, Am. J. Med. 20, 719 (1956).
34. Berman, M., SHaun, E., anp Weiss, M.F., A digita:
computer program for the analysis of kinetic data, Biophys. J. 2, 275 (1962).
35. Stansury, J.B. Et AL., Endemtc Gorter - The Adaptation of
Man to lodine Defictency, Harvard University Press,
Cambridge, Mass., 1954.
36. IncBaR, S.H. anp Freinxe, N., Simultaneous estima-
tion of rates of thyroxine degradation and thyroid
hormone synthesis, /. Clin. Invest. 34, 808 (1955).
37, Rices, D.S., Quantitative aspects of iodine metabolism
in man, Pharmacol. Rev. 4, 284 (1952).
38. Bererwactes, W.H. and Rosains, J., Familial increase in the thyroxine-bindingsites in serum alpha
globulin, /. Clin. Invest. 38, 1683 (1959).
39. Rosains, J., Ratt, J.E., anp Rawson, R.W., A new
serum iodine component in patients with functional
carcinoma ofthe thyroid, /. Clin. Endocrinol. 15, 1315
(1955).
40. Tata, J.R., Ratt, J.E., ann Rawson, R.W., Studies
on an iodinated protein in the serum ofsubjects with
cancer of the thyroid, /. Clin. Endocrinol. 16, 1554
(1956).
41. KuerFer, J. ET AL., Perchlorate test in hyperthyroid
patients treated with radioactive iodine, New Engl. j.
Med. 273, 1326 (1965).
42. Kirxcanp, R.H., Impaired organic binding of radio-
iodine by the thyroid following radioiodine treatment
of hyperthyroidism, /. Clin. Endocrinol. 14, 565 (1954).
43. Wirkins, L., Diagnosis and Treatment of Endocrine Dus-
orders in Childhood and Adolescence, p. 526, 2nd Ed.,
Charles C. Thomas, Springfield, I1l., 1957.
44. AXELRAD, A. AND Lesionp, C.P.. Thyroid tumorin-
duction in rats by lowiodine diet with and without 2-
acetylaminofluorene, Proc. Am. Assoc. Cancer Res. 1, 2
(1953).
45. Grresspacn, W.E., Kenneny, T.H., ano Purves, H.D.,
Studies on experimental goitre. WI. Thyroid adeno-
mata in rats on Brassica seed diet, Brit. J. Exptl. Pathol.
26, 18 (1945).
46. Pasnkis, K.E., CANTAROW, A., AND STASNEY, J., Influence of thiouracil on carcinoma induced by 2acetaminofluorene, Cancer Res. 8, 257 (1948).
47. Money, W.L. anp Rawson, R.W., Experimental production of thyroid tumors in rats exposed to prolonged
treatment with thiouracil, Cancer 3, 321 (1950).
48. Morais, H.P. anp Green, C.D., Role of thiouracil in
induction, growth and transplantability of mouse thyroid tumors, Science 114, 44 (1951).
49. Wottman, S.H., Production and properties of transplantable tumors of thyroid gland in Fischerrat, Recent Progr. Hormone Res. 19, 579 (1963).
50. Dontacu, I., Comparison of carcinogenic effect of xirradiation with radioactive iodine on rat’s thyroid,
Brit. J. Cancer 11, 67 (1957).
51. KNEELAnD, V. ET AL., Comparison ofcarcinogenic effect of interna! and external irradiation of thyroid
gland of male Long-Evansrat, Endocrinology 61, 574
(1957).
52. Linpsay, S., Sueiine, G.E., Potter, G.D., ano
Cuarixorr, I.L., Induction of neoplasms in thyroid
gland ofrat by x-irradiation of gland, Cancer Res.21, 9
(1961).
53. Gocpseae, R.C. anp CuatxorrF, I.L., Development of
thyroid neoplasmsin rat following single injection of
radioactive iodine, Proc. Soc. Exptl. Biol. Med. 76, 563
(1951).
54. Gocpsere, R.C. ano Cuarxorr, I.L., Induction of
thyroid cancer in rat by radioactive iodine, Arch.
Pathol. 53, 22 (1952).
55. Potter, G.D., Linpsay, S., ano CuaixorrF,I.L., Induction of neoplasms in rat thyroid glands by low
doses of radioiodine, Arch. Pathol. 69, 257 (1960).
56. Dontacu, I. anp Wirtiams, E.D., Development of
thyroid and pituitary tumors in rat two years after
partial thyroidectomy, Brit. J. Cancer 16, 222 (1962).
57. Go.psere, R.C., Linpsay, S., Nicuors, C.W. Jr.,
AND CuaikorfF, I.L., Induction of neoplasmsin thyroid
glandsof rats by subtotal thyroidectomy and byinjec-
tion of one microcurie of I'*', Cancer Res. 24, 35 (1964).
58. Brecscuowsky, F., Neoplasia and internal environment, Brit. J. Cancer 9, 80 (1955).
39. Durry, B. J. Jz. aND Fitzceraco, P. J., Thyroid cancer in childhood and adolescence: report of 28 cases,
Cancer 3, 1018 (1950).
. Simpson, C.L., HEMPELMANN, L.H., ano Futter,
L.M., Neoplasia in children treated with x-rays in infancy for thymic enlargement, Radiology 64, 840 (1955).
61. Winsuip, T.W., Personal communication.
62. Warren, S., Atvizourt, M., anp Coxcock, B.P.,
Carcinoma ofthyroid in childhood and adolescence.
Cancer 6, 1139 (1953).
63. SHexine, G.E., Linusay, S., McCormack, K.R., ano
Garante, M., Thyroid nodules occurring tate after
treatment of thyrotoxicosis with radioiodine, /. Clin
Endocrinol. Meiab. 22, 8 (1962).
. Linpsay, S. anp Cuarxorr, I.L., Effects ofirradiation
on thyroid gland with particular reference to induction
of thyroid neoplasias: review, Cancer Res. 24, 1099 (1964).