332
CONARD et al.
Mor
of
Sit
oe:
eee ee
cp ene ine me
lymph node in a 41 year old woman.
The histological cxaminations of the
thyroids showed that in the children the tissues surrounding the nodules
was usually abnormal while the thyroid tissue surrounding the nodular
areas in the two adult cases was relatively normal.
During the recent survey of the Marshallese people in March 1969,
it was found that 3 of the cases with nodules who had been exposed at
less than 1O years of age had not shown satisfactory response to treatment.
In fact 1 case showed a recurrence of a nodule that had previously
disappeared in spite of the fact that this subject had supposedly been
on thyroid creatment.
She complained of a lump in her throat when she
sWaklowed.
One new case of nodularity of the thyroid gland was found
in a 34 year old woman. These cases will be returned to Brookhaven
National Laboratory in the near future for evaluation and possible surgery,
CORRELATION OF THYROID FINDINGS WITH RETARDATION OF GROWTH AND DEVELOPMENT
IN EXPOSED CHILDREN
'
Based on anthropometric measurements and bone age radiographic studies
it became apparent several years after exposure that some of the children,
particulariy boys who had been exposed at less than 12 years of age
showed slight degrees of retardatien of growth.
This was particularly
1 meat ante ie Rete a — F at ner
eee ee
see ee
eae Re are ee
marked in 2 boys who had been exposed at about 15 months of age who were
considerably shorter in stature than brothers who were a year younger. 4]
It has become increasingly clear that the retardation of growth noted
in some of the children is associated with thyroid injury bringing about
hypothyroidism.
This was not detected in earlier years due to the face
that the iodoprotein levels, which, as pointed out, in the Marshallese
people results in higher than expected PBI levels which masked the true
hormone level. However more accurate thyroxine levels during the past
several years revealed that the 2 boys showing the greatest growth
retardation developed marked hypothyroidism, palpable atrophy of the
.
thyrcid gland, development of coarse facial features, dry skin and
sluggish Archilles reflex accion and bone dysgenesis. High pituitary
TSH levels
15
in these two individuals indicated primary hypothyroidism.
T—
T
—T
T
SKELETAL AGE DEVELOPMENT
SUBJECTS #3 AND #5
a
e
ad
uw
=
THYROID
Yooh
a
=
lw
a
tas
z
MEDIAN CURVE
UNEXPOSED BOYS
~4
6E
“+
a
3b
4
!
3
!
6
|
9
=
'2
CHRONOLOGICAL AGE {YEARS}
1S
FiG.5, Effect of thyroid hormone therapy
on skeletal age development in two
most retarded boys,
FK