T 1 T T o EXPOSED ® UNEXPOSED & COMBINED WITH STANDARD ERROR MEANS r= 0.4447 ** y= 12.24 +0671 x 2.70 I 1901 30;— | T @ o T UNEXPOSED EXPOSED T 379 qo COMBINED . r= 0.3901 * * y= 23.830 + 0.5234 x ' - _ go beta 100 20 ** CORRELATION WITH AGE SIGNIFICANT AT 1% LEVEL | 30 | 40 50 ' 60 AGE | to | 70 80 90 30 80 — rol ] TT COMBINED WEIGHTED DATA * © EXPOSED ® UNEXPOSED Q COMBINED WITH STANDARD ERROR MEANS ° r= 0.99 ** | 4 eses es = oO 13 0 SIGNIFICANT AT | %EVEL 1 30 | 40 | 50 | +60 AGE a 70 1 80 | Las 90 proliferating cells of the bone marrow, leukemia occurs relatively soon after irradiation, while malignant lesions of the skin would not become manifest until later in this more slowly proliferat- ing tissue. In the Marshallese the high incidence of adenomatoid goiter in the more rapidly pro- liferating thyroid glands of the children may possibly represent premature appearance oflesions which are knownto occurlaterin life and thus in 3 m™m * * CORRELATION WITH AGE cycle) in a particulartissue, i.e., with more rapidly > y= 0.51+0.38 x +0.01 x? * COEFFICIENT FOR AGE CORRELATION OF EACH CRITERION USED TO WEIGHT SCORES BEFORE SUMMING oO ° ° | + '80 | at an earlier time than it would ordinarily be manifest. One aspect of this phenomenon maybe related to rapidity ofcell proliferation (generation a mM oO PERCENT AGING ° | 20 : Figure 47. Cholesterol (1957). T 60— w | 10h e Figure 46. Potassium, males (1961 and 1965). 190 1.52 mg PERCENT 3 305 PERCENT PERCENT g/kg BODY WEIGHT 2.3! a sense represent an aging process. On the other hand, the fact that no tumors (except benign nevi) have been noted in the heavily irradiated skin of these people might indicate a longer induction period due to slowercell turnover of the skin. In considering future aging studies in the * * CORRELATION WITH AGE SIGNIFICANT AT 1% LEVEL i 30 40 ! 50 60 AGE | 70 {| gO Figure 48. Biological age scores. dt 90 Marshallese it is hoped that more sensitive tests of vigor and organ function suitable to the condi- tions of study may be used. However, it must be borne in mindthat such subtle aging effects may not becomedetectable by ordinary clinical means