Table 20
Growth and Thyroid Studies in Subjects With Thyroid Abnormalities
Neck '*7]
at 4 hr,"
% of dose
Growth
Subject
4
La
No.
and sex
Year
Thyroid
abnormality — tested
3.
M_
Atrophy
3
M_
Atrophy
Chrono-
logical .
age, yr
Skeletal
ranking,
yr
Statural
ranking,”
percentile
1965
13
3
<10
1965
1966
13
5H2
<10
1966
Pre
TSH
Post
TSH
Serum iodine,
pe%
PBI
0.8
> 120
1.9
3.1
0.8
1.8
119
248
<0.5
372
<0.5
440
5.7
1.7
125
17
F
Nodular
goiter
1965
1966°
{5
13%2
90
6.8(’64)
1.8
21
F
Nodular
1965
15
15
10-25
8.1(64)
69
F
Nodular
19654
16
16
2
M_
Nodular
1965
13
112
25-50
20
M
Nodular
1965
19
Adult
25-50
72
*F
Nodular
1965
18
17%2
>90
42
F
Nodular
1965
15
13%2
10
61
F
Nodular
1965
20
Adult
50-75
54
M_
Nodular
goiter
1965
1966
13
13
90
19
M
Nodular
1965
17
152
10
36
M_
Nodular
1965
19
18
75
33.
=F
Nodular
1965
13
13%2
>90
65
F
Nodular
goiter
1965 —
1966
13
10%2
<10
59
F
Solitary
1965
35
64
F
Carcinoma
1965
19664
31
40
M__
Solitary
nodule
1965
40
goiter
goiter
goiter
goiter
goiter
goiter
goiter
goiter
goiter
goiter
nodule
1966°
1966°
1966¢
1966
1966
1966°
1966
1966
1966
>90
1.3
7.1
6.5
18
TSH,
ng/ml
1.4
3.2
8
T,I
Serum
1.0
(29)
(23)
7.9
4.2
(31)
(31)
6.5
4.2
5.2
2.6
159
9.6
26.6
5.3
(15)
(24)
57
46
12°(10)
(24)
7.9
49
8.3
5.0
4.3
<3
<17
3.9
3.3
<17
4.3
<17
197
19
4.1
4.2
7.0
(16)
(24)
59
3.8
(9)
(14)
4.9
3.
2.1
1.9
7*(20)
(38)
8.2
5.3
(19)
(28)
86
4.9
3.4
2.0
17
86
<17
7.3
6.6
23.5
4.8
10.3
“Values in parentheses obtained at BNL.
>Relative statural growth expressed as percentile ranking compared with growth curves of unexposed Marshallese
children.
‘Assays in 1965 could not detect levels below 3 nanograms/m]. Seven unexposed children in the same age group had
<3 ng/ml. Assays in 1966 could not detect levels below [7 ng/ml. Three exposed children without thyroid disease
(Nos. 6, 8, and 32) had <17 ng/ml. Two children exposed tn utero (Nos! 84 and 86) and two unexposed children had
<17 ng/ml. The 1966 levels were obtained about 3 weeks after cessation of thyroxine therapy, the 1965 levels, before
therapywasinstituted. We are grateful to Dr. William Odell at the National Institutes of Health for carrying out these
assays.
,
4Post partial thyroidectomy.
‘While taking thyroxine.