37 Table 21 Kinetic Analysis of '**I Studies Location and year Marshalls, March 1965 Subject No. Exposed? Unexposed* Thyroid fraction‘ 1.10 (0.34-2.57) 0.67 (0.33-1.27) 0.40 (0.25-0.65) 0.81 0.79 lodide Space. liters 0.52 (0.23-1.47) (0.26-0.77) 1.20 0.80 1.71 1.19 0.41 0.60 20 pre TSH 2.12 2.30 0.49 64 pre TSH post TSH 1.88 0.81 1.08 1.56 0.36 0.66 0.52 0.005 0.01 69 (partial thyroidgctomy) 1.13 0.15 0.12 33.3 2 (partial thyroidectomy) 1.53 0.92 0.37 20.0 61 (on thyroxine) 1.26 0.58 0.31 29.0 54 0.50 0.69 0.58 65 1.08 0.72 0.40 20.4 59 (on thyroxine) 1.65 0.10 0.06 16.9 42 pre TSH post TSH 1.87 0.69 1.29 1.30 0.41 0.65 2 pre TSH post TSH post TSH Marshalls, March 1966 - Thyroid," per day (0.17-1.99) BNL, June 1965 BNL, June 1966 Urine,* per day 3 5 1.10 0.86 61 pre TSH 1.81 0.14 | 0.62 O14 post TSH 0.50 0.13 0.48 0.78 33 pre TSH post TSH 0.20 0.45 0.97 1.57 0.82 0.78 1.83 0.82 65 pre TSH post TSH 59 pre TSH - post TSH 2.35 3.53 1.29 1.67 0.77 0.31 1.14 0.33 1.51 0.30 3.09 0.71 *Fraction of extrathyroidal iodide excreted in the urine per day (A,,). *Fraction of extrathyroidal iodide transferred to the thyroid per day (A,,). °Theoretical thyroid uptake, A,,/(Az.+As:)- *Mean and range of 12 subjects. *Meanand range of 9 subjects. signs of hypothyroidism: coarse facial features, dry skin, and Achilles’ reflexes with typical sluggish return. There was no palpable thyroid tissue. They did not show apparent mental retardation, TSH levels (Table 20) were markedly elevated in both boys, corroborating the presence of primary hypothyroidism. Figure 28 shows bone age retardation in one of these boys. Typical bone dysgenesis associated with hypothyroidism** was noted in 1965 in these boys. Figure 29 shows such changesin the headsof the humeriin onecase (No. 5). From Table 20 indications can be seen that sev- eral other children with thyroid abnormalities (subject Nos. 2, 20, 33, and 65), some of whom