26
Table i4
Serum Iodine
Serum Protein-Bound Icdine
Date
Group
Average, ug%
Range, ug%
No. samples
Percent over 8 pe%
1959
1962
1963
1964
1964
1965
1965
Rongelap
Rongelap
Rongelap
Medical team
Rangelap
Rongelap exposed
Rongelap unexposed
6.2
8.6
8.1
49
7.1
7.6
7.0
4.1- 92.2
4.6 - 12.0
1.9 - 12.0
25- 69
2.0 - 10.2
43-119
3.9 - 10.7
12
14
29
10
11
31
19
16
64
66
36
42
28
1966
Utirik exposed
11.8
6.9 —- 28.7
25
92
1966
Rongelap exposed
6.1
3.1- 11.8
19
16
Serum Butanol-Extractable Iodine
1959
Rongelap
4.9
2.7 -
8.7
12
Serum Iodine Chromatography
Group
Total iodine, Av 4g%
1434-1964
1965-1966
Rongelap
Rongelap
6.98
7.40
2.22
2.80
4.53
4.21
19
18
1964-1966
Americans
5.09
0.80
3.76
25
1966
Utirik
18.10%
lodoprotein, Av ue %
9,20
T,+T73, Av pg%
No. samples
4.00
5
*One Untirik sample was quite high in total iodine (32.0 ag%) suggesting contamination of this sample. The remaining 4 samples showedtotal iodine levels very nearly equal to the combined iodoprotein and thyroxine values.
tion in PBI is a general phenomenonwhichaffects
the entire population. —
The difference between PBI and BEIin 12 cases
was 1.5 ug%, which is somewhatgreater than an
average value of 0.6 ug% in the United States.**-*?
This was suggestive evidence for the presence of
iodoprotein in serum, and theresults obtained by
large consumption of seafood. Analysis of 24-hr
urine samples from 28 people at the Boston Medical Laboratory in 1965 gave an averagevalueof
105 yg iodine per day (range: 19.5 to 279), which
average iodoprotein level of 2.22 ug% was found.
Thyroid Uptake of Radioiodine.
Uptake of
radioiodine by the thyroid wastested in 1965 on
column chromatography substantiate this, as an
The average value for the amount of thyroxine
iodine plus triiodothyronineiodinein these sera
was 4.53 ne%. Five plasma samples from Utirik
people assayed in 1966 showed an unusually high
average of 9.2 ug% of iodoprotein. (See Table 14.)
These data may be compared with results obtained on 25 normal North American controls residing temporarily in Washington, D.C., who
showed an average serum iodoprotein level of 0.8
pe% and an average 7,+ 7; iodine level of 3.76
ug%.
Dietary lodine and Urinary Excretion of Iodine.
The supply of iodine in the Marshallese diet has
generally been considered adequate in view of the
is within the range of values found in an unselected population living in the Eastern United
States.** A complete table of urinary iodine ex-
cretion data is presented in Appendix4.
21 Marshallese (12 exposed and 9 comparison
adults) with no knownthyroid abnormalities.
Studies with '**I were performed witha collimated 1-in. Nal crystal 25 cm from the patient’s
neck. The '*7] was milked daily from tellurium-
132 bound to a resin by elution with 0.1 M
NH,OH, and it was calibrated against a *°*’Cs
standard. The ‘*7I (5 to 10 wCi) was administered
by mouth before breakfast, and counts were obtained over the neck at =, 1, 2,3,and4hr;a
single 3-hr urine was assayed for ‘*7I. A predose
count of the neck was performed, since a small
amount of what was presumed to be **’Csin-