c enzyme systoms is Knowledge of pattern of chango of tissu ; sought. ; be quick Procedure: Tissues obtained os in Belesee Will Fronsn at 4-5S°C and transported in this state to the Army Medical Conter for enzyme system studics. NCT** — Responsible jgoncy: Notional Cancer Institute ion radiat bomb atom the of s effect the Objectiver To study a source of on the hematopoictic system, on longevity, as mice. genetic effoct, and as a carcinogenic agent for ces Procedure: Animals would be exposed ss in 3.2.1.1 sat distan ups Ghore sublethal doses could be expected, Long term following and breeding studies would then bo conducted after return the animals to the National Cancer Institute. Project 3: Bele Sel Responsible Objoctive: area burned Procedure: to separate Study of Thermal Injury Agency: National Military Establishment To study the relation of the mortality to surface and to the degree of the burn. An attempt will be made by suitably timed shiclds the majority of the thermal exposure from the ionizing radiation exposure. ‘Suitably shiclded pigs will be placed where burns of varying severity can be anticipated, The influonce of the burn on mortality, end as a complication of radiation injury will be studicd,. Zeladed Sele bed Responsible 4eeney: University of Rochester Objective: To comparc atom bomb flash burn with matcrial from Bikini, and with flash burns produced in the laboratory. Procedure: Suitably shiclded pigs will be placed where burns of varying severity can be anticipated, The histological character of the burns, and related phenomena will be stucied in an attempt to evrlunte other atom bomb flash burns, and laboratory flash burns, Responsible Apency: Argonne National Laboratory Objective: To analyze histologic changes in tho skin of pigs exposed to thermal radiation, for comparison with the findings in the skin of the victims of the Los 4lmos accident. Procedure: Young pigs would be exposed, suitably shielded from blast, and by timing devices from some of the ionizing radiation, Specimens of skin would be removed,fixed and returned to the U. 8. for study. Project 4: Seleded Study of Blust Injury Responsible Agency: Objective: Netional Military Establishment ‘fostudy blast injury using improved containers basedonexpericnce at Inyokern and Bikini,’ There were serious discrepancies at Bikini between the degrce of injury and the estimated overpressurc, with lethal effects from peak pressures that are not lethal with H.E. Further study of this is desired, Procedure: Small animals, shielded from thermal radiation would be cxposed in various positions related to blast measuring devices, They would be sacrificed as soon as recovered for study of blast effects, Project 5: Buael {Part M-5) Study of Simulated BW A,-ents Responsible Agency: National Military Establishment Objective: To study the effect of atom bomb radiation on the Simulated BW agents currently under study by the Chemical Corps, Proeedurc: Simulated agents, protocted from thermal radiation would be cxposed at various stations where predetcrmined radintion intonsity is anticipated, Bacteriologic studies of the growth characteristics of these agents would be conducted at Eniwetok and in the U.S, ** Proposal submitted too inte for action by Committec C- 2 AD AUITITC 3.20464 cont'd RN - woah