4 Se on ‘ RESEARCH PROJECT AT(30-1)-1243 TITLE OF INVESTIGATION: z 2 . HG. $200 ; MN, 6S” Rei hi A Study of the Physiological Fimctioy ami Histo logical Changes in Thyroids Irradiated with Radioactive Iodine PRINCIPAL INVESTIGATOR: Brown M. Dobyns, M. D., Ph.D. Professor of Surgery, Western Reserva University INSTITUTION: Western Reserve University School of Medicine at Cleveland Metropolitan General Hospital ‘ ANNUAL REFORT - June 1, 1966 to June 1, 1967 407559 This project has represented a broad study of both physiological and morphological changes produced by 131I in the thyroid of both fnimals and man. Early in the history of the project much time was devoted to gathering kinetic data on patients treated with 13217 and observing the associated changes in the physiology of the gland. Gradually bore tize has been devoted to morphological changes in these human bids and to animal thyroids with special emphasis on the fate of the cell,j/its potentia® for mitosis in normal replication and neoplastic change. Muchjof what has been learned and objectives in experimental design have been ated to two other important national studies of the Division of Radioligtcal Health, with which the principle investigator has been associated. One is the study of nodular goiters in children in the atomic bomb fallourf area of Utah. The other is the cooperative radioiodine therapy ‘=llowpup study of which the responsible investigator is the chairman of <e Sfeering Committee. A very detailed report covering all activities of this proj beginning vee submitted two years ago. will The Study Given brief. on Radiation Effect on I Because of this some of oid Function in Clinical t from the the review biects Early in this project enormous amounts of time were devotedito collecting: very detailed data on selected patients who were given 131I thdrapy for hyperthyroidism. Only selected patients could be used becauselof the inordinate amount of time required for a single patient. The nical effects | of 131] therapy have been ultimately weasured against a large eckground of data on each individual patient. It was hoped that in this|way, it might be possible to find explanations for the great variationlin the response of different patients to this therapy. There are maqy studies that have been done, and are being continued, on each of the sqlected patients. This has been discussed in detail in the previous rqports, especially in the lengthy review submitted two years ago. The jiseries of observations on each patient are therefore merely listed heye. We have felt strongly that only subsequent interpretation of the effects of radiation can only be evaluated on the basic of very detailed Winetic data and the changing pattern of iodinated compounds in the blood rather than the superficial observations commonly made in the course of clfmical follow up of the usual patient given 131r therapy. DISTRIBUTION] OF THES DOCUMENT 1S INU: BEST COPY AVAILABLE