TURE Ady et rhe “4 soe fre Me ee Te aedali ae be teat aal ke > Aes eae x ayer +? rg a ee BSeeEA . at ‘ag . a that the Ynesr no-threshold model can aehther be supported nor refuted wii: much darger nonabers of exposees i the I dose demain, A full-blown oo :travers) bas roped ate >this mater and stl orobably not be settled tae , emes saustacuon und? studiss now it progress or planned can be complered, Tee destal expert can couiibute saanicanth, and show clearly ui. the aqasver is moi a sunpie one. Mays & Lhord (110) summarize 3 exiernss.CADET TICES meobeing vraded deses of radtostronuum and radiocalerim « Wes, ral, pig and Gods. A linear relation does not ft the dose-respur‘ relanon very Ww al in anv of them andat low doses there 1s alwaysa lower Inciden:(frequeaiy zeros tnan predicted by a linear extrapolauien with no threshowd. 4 sariid type relation fits better. By contrast, the analysis by Mays et al (79) cz sinedar expercimenis wit) acpaa emitters (pluronium, rudium, eto.) shows a bot i tO a uncar po-loresnold celauon than io a sigmoid one. Tamplin & Govma: (id3sinsist that ine ficear hypothesis is the only one mat fits the beaule-dog da: . for alpha emitters. [f there is really a difference between the aipha and beta o: bela-22mma emitters, as Mays’ analysis suggests, the direction is consiste: with known differences in cell and tissue recovery fromeffects of the two king of radiation, although other explanations may be just as valid. An example of howrisk estimates differ with the model is seen in the analys « of Mays & Lloyd. At doses below 1000 rads the projected risk (in man! in 7) years is 1 >: 1 sarcomas'!0® person-rads for a “low-dose lier model” 4 -- 4 sarcomas '10'© person-rads for a dose squared mode! Thus the dulfere is not trivial! Other models have been presented. Rosenblatt (146, 147) utilizes a ince dimensional surface logistic model to account for simultanecus contribut . of Ce au and lime on OsiePGsaflConig iwidence in Deagies FecelViNg 3Pata wn ft radtastrontiom. and omplovs the Cutler-Ederer fe tndle onnhed (te treat: ag deaths trom causes other than the one az issue. This logistic .voe re se iS not linear anywhere. Also, it permits age-related incidences th be calc: wie fe... 10° cumulative osteosarcoma incidence would occur ut ace 2 o beagle} It is discussed in detail along with risk evaluations based oF Goldinan & Bustad (49). Mole (150) describes the probability of bone tumor in mouse and dog iscsi. ; 9°8r as directly proportional to the square of the number of bet 7 urvicte envtied in the skeleton ser KHegram beady weight. This did mov appear ts have. sowner for cipha enatkos. Re also generals bat ine dle ba dtaal ab wtiiey ca'v*it, rat, and dog deren nstrave essenually equa! cucic sensitivns of We cide dst rendosteal ceilsi, a somewhat unexpected phenomenan. Tonetiv. as remarkcd by Evans ef af (37) the finear nonthresnald mod. Sy. ie Une sume vurcer of angered tinhs duals per perso i-rad regardless . se Hae exposere gest cs sobdivited ioune exnmoced graun. Tris has ae. ew been ouos the somade effects of calation alth rat to be tue foe cene ic etfecrs loa ogy, It must be oovious from al! this that none of the studies, man or anim: rk se :. wa i * it ann) ’ . It wo - t moe | wd el " L oaths . io é é stg Sb sy fue om 4 ‘ “ aed ‘ a . oH my coe meg ot guy ee . TO 5 . . 5 eg . $e TE ideo ty ae Hp ame 2 we: roe Dobe eth de ate! ss ” tea | ! Rye dw Ae x Bergier 7 pe eons ky fF ot gd hve! gad sgh . : . toy we eee ed et . hy i. igh : ue : + +. bor’, aa : Ae 4 : q ™ — Kis . 4 yt ha I . ee at Tepe pes tgs Be EN. rae Lact ot fae bye 9; US Se arenery mgs a. "paul “hae“forehtey? rang hee pe sped i REFEEooh ee watt es Pepran oieul & MAG=, ee \ 3 . Nanny tae a is : : t Ug ve pe ’ * ep Mh hay ote. . yeti Res . qe Bae Pata, Toe at aa . Ste: a et te. DORMS ph tae Ra ARS beSES toa gy BMwennppeanS binEI ep blade bs a e seth? : Sop s lo, t : = Boe rine. oh ac. “ Pr < . FURR, a work eo. 2 we + ae eae me ~ ete eg RE A Wee Ta Pe tee . ot ‘ tat eg eet ah tl age re he ee, ted Are Tp Poe x shige ae - Ra Me voy r Fy ~ ee eye et i = oo V+