‘ 7 : . ; i Loan ake dere on tants Malasar Ra od bacLot ba Hanne. Yet the body burdens of all isato a. i as 2Sr- VY are se tow (weil Be. 4 tonal exposurs) that U2 autaer aceupa pr rathogenic. They suggest a longer perins hos. croup, before conc.iding that thos. exposure. ated oy the presence of radium ceeua in ‘ 4 ereater than those of radium or cesium, fastronuum exposure, sted be relatabie fo ru cr analysis is important since the ” eual Phat ionizing radiation can and has wats Sear 12; | Prinary2 interest fer this » eanused to fall-out aad patients receiving “yd diseases. The fall-out exposures are in the studies with ratients, '?'T seems . 4 L . rad “i. unyroid carcinoma than comparable itor of about 10. a oat ‘ nnd 135] seem to be more effective in pro- ta tstad dases are more similar to external that this difference may be due to the colloid along Poi line isotopes in follicular to the other red compa e particl beta 'd eo wortaid varcinoma in chitdrec. for external . Ws-rodiatian and gamma ptotons) 1s 10-20 Voy t yecrased persons (114). The nsk from ~ { al vases per rad per million in children and cdence from X-irradiation are about mo Pe posees. wuhemia than from thyroid carcino.24, wet the chances for leukemia induction trom +. raraicosis. This has received more emphisis ' carcinoma. In 1968 Saenger. Tioma & ete 1! repert on a group OF 36.000 oatians “Ythat there was no differen ein leukemia “Te f or thyroid surgery. Bu tach other teakenna for hy perthyroid pa: IML» asa sine gereral OLS. 7 Soper. deta dee ste . bowtie Rave bea dane. f “naeaes “erenege eee Tan mt PTE : ops= aes — - - Indnetion of carcmosamal aberrauens by iodine-isotopes has ben repozted Niuwi. of the oat srTeation on ‘adiis-isctopes in animals utilizes reiauvely high ee fons. Recently Thorius, Scou & Chitcile (20) have reperted on the abhi daw ide. uy ol cy ISTE pot oniy at moder Rey sud una injected aie COse fewets But ot levels wos Jerel in the past as “contrat” or “tracer. The average infinite beta radiation uoses to the thyroids of these animals ranged from 797~4510 rads. The lowest infinite dase was 286 rads and the highest 18,603 rads. Thyrcia tumors, usually foliicular adenomas, occurred in ahi animals including the controls, but tumor incidence in the higher level animais was greater by a factor of about 3 over that in the control and low-level groups. There were also alterations in the pituitary gland with pituitary adenoma occurring after moderately high dosage. It 1s interesting to note that theve was no ahereticn in life-span in animais maintained for a longevity study ©. tr tnough some of them received accumulative radiation doses to the thyroid of approximiaely 15,000 rads. However, biological change of a greater cr icsser degree wus seen at all of the dose levels. Other heta aid beva-gamune emitrers.—Bair (9) summarizes the incidence of wie bite weer “Ce give n by wiuratricneal injection, ‘“Rae '' oan peiles itnpeontie *} irap.ams, Co wire implants, '78Au, “"Fe. 27S, and '?Ru after inhalation or injection. Sanders. Thomoson & Bair (12!) give an ex.pertment-bs-exnerimert review. Radiation do:2s to the lung are so high in WV thare mitences itut it ts reasenable to conciede chat these nuchdes are celaiveny incficien: Curcinogenic agents. However die studies do not ordinar:ty melude many Jow-dose seginents or sufficient :ime really to determine the iong-term potentialities of these nuclides. There is a report of teur squamous ci! care.La. vey DDR ds ocape Cphaling '44Ce csils in ameunrs weoducicg es fo. oe only up te 2500 ra. s and a Jarge studs “ith dogs recviving 1440Up cu rmeraiue ints furcd eh iss crogress at the Leve.ace Foundation, Berke & Desc. ant hod move polmoraery pathology than neoplasiic change in rats receiving vrese 5 ‘so, tom soma [ED-18s, aeToi. dt; “4 TRAPTES Batjeeaa “he i rae apenas an gine LE PORamee 5 in meth animate C87 UeRy and mar t1igs fe cel rary ve wad thes fans sos whe BAST. Or takeout than uses an iWQlly. pioneer don, i fase . 3 i oO a he a AST J, can produce thyroid virog, cramarify - Pate There was an epparert excess of acute leukemia m males receiving #311 (5 cases obserscd vers LS ¢ pecied) and a comparable Ceticit fu boc sexes In viieihee Of a SRTapa Gc kee Komid (Zit onserved versus 4.8 exrecte Trese undings ate .ompared to and touad consistcat with the data from the ankslosing srocds lings and aren: bomb survivors. Torepams con udes thai none of the siuaes demons rate induction of .eubkemia at low total-hody deses ef radiadon cad thot)" 2 ucatment of thyroid disease curries no greater risk : . ‘ ne RAE tes AR beetOS th tae re Ae wehteek ew abe = Ga beas A Ta RAT Ae oa ND DOTE-ETSPONSE RELATIONSHIPS ‘ eowy. Parabooeos far udionuchdes 2re Mu? mere tame. aw ut huis -Jaci’ vl Matiad. oes of loxcalogy, Tas arises in farce pithe preci of radiation aici mests not to be satisfied scith such simple woes TEre mM7 Pa aT meyer TET PTeres ipane Se a” anid Ve 47pias ptinbeapt ”" ageToot gPantpterhe epeage st Whingg Hae ewer nae ety dg Jot wy ane eo wer ‘ POT be te ae ete oe Win Be whee ny yt TR ad bet thee we Faget 1A a otideet he ieee speitie ate ed eeap oe . tos patent ph ee kre be eee hla deg Tk Dh avy rae seat