see Hy ey Oe ea a a wo) MARNE Ae Oe hon ote cate ogee teafe Foi mel er Ans ‘ 4 4 o 1 the parnt and in the body buraen, furtiler anacysis is iMpurtuni since Ue . curdens are generally conviderably greater than those ¢f radtuen o: and eects, if they do aapear, might thus be relatable to radiostroniiut. WA 4h hag a 1 pete Ly , ‘ ode ot . rion \ de Tem ‘ i uy vy Poet @ ‘ tog , tae PO oy ty ", ote rea yt gr Te wry che OK ae a aL | ’ Bere wee co ho A general estimate of the risk of thyroid carcinoma in chi'dren for externa! soe Tt bp with the relatively low energy of the ‘?'I beta particle compared to the other iodine isotopes. ’ forms of ionizing radiation (largely X-irradiation and tame plorons: is 1C-2> additional cases per rad per million exposed persons (114). The risk from 1344 would thus be about i-2 additional cases per rad per million in children ani Jeis in adults. Estimates for leukemia incidence from A-irradiaiion are about 29 additional cases per rad per million exposecs. In view of the greater mortality from leukemia than from thyroid carcinoma much concern has been expressed over the chances for leuxemia induction fron, radioiodine in the treatment of thyrotoxicosis. This has received more emohas:s recently than the induction of thyroid carcinoraa. In 1963 Saenger, Thoms & Tompkins (11S) putlisned 2 preliminary report on a group of 30,0uU pauenl (with 98.8 °% follow-up) which indicated that there was nc ailference in leusena incidence between patients receiving '7'T or thyroid surgery. But wich ertce: treatment the odserved mortality from ieuxemia for henectoyretd peneqs 4 group Was reporied us 50°54 higher than for the general U.S aap an Pr kins fodowed this oreliminary ry report with a more dara fot ots: moe rep The age-ad:usted feakoimia incicence rate was id per bor itad papers 5 foe wo a vadbyt yohalg . oe vite Bay wre mp ea? edt ere “| . at ¢ » eanwgSt ' Set‘oh . ‘hovige Adin . ih vieHT Spheres jaieed “ ee wf me ree ducing thyroid carcinoma, and calculated doses are more similar to exiern. radiation. Casarett (113) speculates that this difference may be due to Ub. extremely nonuniform distribution of iodine isotopes in follicular colloid alors ‘ Hage wt tie te * ota, “om nee wba! 3 wey, t ¢ . Choe - Other iodine isotopes '371, '354, and !351 seem to be more effective in ihatiety: pies “ ideale Redicivdine.—The fict that radioiodine, primarily '7'T, ean prot. es 2 carcins na im: animals is well-established. That ionizing radiaron .tr 2 + > procuced thyroid neopasia in man is also clear (112s. Pruvniry i review centers on the populations exposed to fall-out and peticits rho radioiodine for the treatment of thyroid diseases. The riil-cui exmv 3. considered under a separate heading. In the studies with petients, ‘7 'f secc considerably less prone to produce thyroid carcinoma than comparable rac doses of external radiation by a factor of about 10. fy oO iY, ooge os Alingugi the groups are complicated pv the presence of radmiry ie tens ees ue ud PCs) Radium C. and radon as well as “PSr-°FY are se dee ree maaimum permissible bods burden for occuranoanal exsposars, thot 7 ol. refuse ta believe the careinomias to be radinge te They suggest a for ger of hehew-up and further anabysis of the group, before corciudiny wat iy true incidence due to radiosircentium exposure. Bee, ory ‘ 1 , eS 6 cases of malignant disease is only 0.0006, Yet the bods bur sis of eeu Get 9s “werdirapyerethus : Op Bae choad [4h oF. the ‘3 J—treated patients and 14 1a those treucd otha - lack of a gross increase was confirmed, althcugi the cov erse : ot confirmed, as a muchlarger population would have been uceded to prove this wp . « on neg o a) Jf oxe 4 emir men PereyCEPR . “4 , wes sym he : : Foam tg OMe Menge, NM “ > rs Lat bee nen ToaT: IES a wee wo le po ye > eg Reed Bed ma ‘ yd foes va ae Susy tad 8 AED AR, weed teh) yang phatree Bots Ges et woes i a roar Bee Rone t ae Ya ~ a t ee . EB peeteear bet :Baye . . “ : > PEK wary wer ye ser meee sae wa SOR Te gy e 1 “ waded a Qhag ak Ardde pe theme sndagfaeteh ce gaee vena ag Hilbe dbasenl ANIL RS oe fob fe‘esa‘Rewketa ckRn i ed ' , , r ne bos » oes TaeSs “aut ‘ as sot . mo . toa, hayRN ee YR 4ee me Boca . yYy.4 x eae os ane . te eh fe ora dpegby oo i et 4 ath Mey 6 OS r eA G we