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aie osteosarcoma. be wainria.lreoma, and fibrasureamc in bone as well as
enidenmota carcinamia onthe orsi und rascal cavinigs, ivenphosarcema, myeloid
ao opdorenicusa ce a! CaP TARE MES SOIT. beagatoneicel fata tes
tthe Utah ouperimants,
fugestod Sr has buca esutlaied Woaili wuRSMOBENS tiecrs Ga bone marrow
acd the ivmphereticu ar svete? Of noouuture swine as Cescrébed by Clarke et al
(sp while Pool et abciaty renert a pen tnerdence cf nore sarcoma in beagles
rors Ing quile larie radiation doses how "Sr received hyJAwestion.
MoCleflan & Jones (FOR) have ceemmanze? cogently cuch of the information
O+ tumor incidence with sadiestrosmatanii andrdals. “though sinall chances in
lew pacture have occurred in the 1a. tin, ther Table 1U ts such a usefu: Summary
Nei ditis vepreducee oclow(Tobi t.
“ur experience with lahaled screctum (109) shows also a predaminence of
vuvuars Of pone sinier te the Gian acd Argonne National Laboratorysiudies
wih dogs receiving, single intra -encus injections. This indicates that the inhaled
suiicrugm compounds are re-oivess roore mobile than some of the insoluble
o ides such as Putd, and that bone .. apt to be the chief tissue at risk with
v 7a. t a3Jaot va: yy
he Hd oY
qe ey nh
she
ste gab dee.
ihe .
Pete t asates
wo
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tat mgs patsyae
ow
4
strentium, regardless of route o1 entry, as long as the doses are small.
Jl of these studies showsvrancdun to be considerablyless effective as a car“aggen in Bone than radincn and the other alpha erritters. Its effectiveness
igative tO Tadnoie sa eae Ccande capecument at Utah is about 0.07-6.24, and
woilar effeciuve iiss cuteas canine calc icted from the other experiments.
In dogs inating ?'SrCi., cakwieted cumuluive doses associated with neoplasms rangeu ‘rom 4UUL rads to as hign as 22,000 rads (110) compared to much
ihackr sioses aAssomated wiir snot. cegcees af development of bone sarcoma
.
:
Gon
WEED Pu0dy), Pron,
apa ove
a.ote emuiers. The new eaperiments coni
.
CP TN pp dey
aD
Pe wt ree isis by bets sad beta wamma
evaters thon a onint
'
ube et
oii. apeiesxcipt fer the worldwide popula“Ob USPUSCG tO Maheoba, ob be Grollst sit separ.i2).-, there is only one discrete
rapitation oF human aysiibts for esidemiolecies! study which has had exposie Wo radiostrontuit. For a short period lurainous dial painters in Czecneslovakia and Switzerliid used a compound containing °°Sr and 77°Ra. Volf
(107) reports on a ercun of 103 cases. Maller anc. ccntrituters G11] veport on
3Oup Cr G2 case, fasafid SasoID, iA tines. gra up, Vile ciiuiivedise
abnoraegties wert se obt ueuble Gee conuel rate ans posidve cunical findings
J OPCAred, HO TOP ws a owcurred mat coud te aiteicuced 19 the radionucilds
OY SOFETE Bone ey co e Wewcesir. ras “er compen There were only 4 case.
Pye yoo, ase
iCerter tho on SEAM TEMPTING AE body curden for
Mapes ~ 7
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individ pe eo. ae Len of thetr study is deveted te alysis of thi:
feature ang te phos ue ckinene stalties, They do rerert 6 cases of carcinoma
with incideuce in 2°. un: vata! group so low that the probability of secing these
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