Nuclear Medicine Technology and Other Project Title: 17. Health Applications Lymphocytopoiesis and Transplantation Immunology Expected Results in FY 1974: RX-01-03- (4) (Cont'd) A study combining 98 allo-antigen and tritiated thymidine as markers to follow thymic cell migrants and their peripheral fate will begin in late FY 1974. ECIB treatment of chronic lymphocytic leukemia will be reactivated as patients under study in out-patient department require therapy. If Nassau County Medical Center program on renal transplantation commences, BNL will apply ECIB pre-treatment to patients randomly selected by age,sex and disease state. 18. Expected Results in FY 1975: All studies reported for the previous year will continue with directions determined by the new findings. Lf and when a biochemist can be afforded, studies on separation of the lymphocytosis factor from B. pertussis will be once again undertaken to search for an agent that may potentiate ECIB in preparing animals for kidney transplantation and patients for treatment of chronic lymphocytic leukemia. It is hoped to reactivate a long dormant study on ECIB therapy of acute myelocytic leukemia evaluating the effect of transit dose on survival time and morbidity. Thymic cell migration studies should be phased out during this year and studies on immunity in diffusion chambers intensified. 19, Description and Explanation of Major Materials, Equipment and Subcontract Items: FY 1975 Capital Equipment: _ The major capital acquisition is an automated autoradiographic grain counter and cyto-analyzer which would replace the traditional visual counting proc supw laboriously accomplished by scientific and technical personnel } Which drastically limits the rate of data acquisition and analyses ration systems and thus the number of patients that can be studied, uipment will be used in the research reported in four separate budget activities the cost is prorated $25,000 each to RX-Ol-Ol-a, RX-01-03-d, RX-03-O1l-b and RX-03-02-b, Another important acquisition for the hemopoietic studies is a blood cell separator to improve the separation of cells for (See Continuation Sheet) 4419234 RX-76