-3-
*
purpa, end hypexia due to anemia, any one of which may be fatal,
Many detailed -
descriptions of the pathogenesis of these phenomena have been published (1-4,12-16).
The above picture
of radistion syndromes is based on animal experimentation;
however, human experience particularly as observed at Hiroshima and Nagasaki and
in the Marshallese natives has indicated that man probably corresponds quite
closely to the general mammalian response outlined above with the exception of
some differences in time cf occurrence,
The CNS spparently was not observed by
the Japanese at Hiroshima and Nagesaki,
One would not expect it to have been
observed since doses to produce this syndrome were well within the area of almost
total destruction,
The GIS with deaths in the first week are well docimented
clinically and pathologically as are deaths from the HS.
However in the case of man,
deaths from infection were most prevalent in the second to fourth weeks (maximum
incidence during the third week) and from hemorrhazic phenomena in the third to the
sixth weeks (maximum incidence in the fourth week).
In the Japanese, after the
bombing of Hiroshima and Nagecaki, deaths from radiation injuries were occurring as
lete as the seventh week.
This is in contrast to other animals where deaths from
the acute phase are uncommon after the 20th day.
PROBABILITY OF SURVIVAL AS RELATED TO SYMPTOMS
Predictions of the effects of various doses of gamma radietion are essential
to military and civil defense rlanning.
If the absolute sensitivity of man to
rediation were known, and if it were practical to determine the dose to groups
under catastrophe conditions, a realistic statistical prognosis could be made.
However, these predictions cannot be made accurately at the present time.
Problens
involved with estimation of dose received by the injividual, present real practical
difficulties,
It is probable that dose estimates will be available from dosimetry
devices or-from dose contour lines and the position of individuals during exposure,
The difficulties of relying heavily on the dose estinates for a single iniividual
are apparent.
-The exact position of the individual and the degree o@ shielding
DOE ARCHIVES
3.