ef wnhis new infor.aciion and the reactions and recommene, the Division ot nadiolosical !Eoaztn is programing 0 ms oO tu Fu © 4 . 3p wow res 20% rection of its biomedical prozrams to place greater emphasis on t's Chg wf & pf. + i ad ey och @ te pO 3 NEW AND EXPANDED STUDI"'S ON TINROTD TUMORIGENS ucies that may clarify the etiologic significance of radiation in the oduction oF thyroid tumors. However, other program commitments and u geucary aud personnel cellings provide only very limited latitude for iwpaed 4 irection SASAy of effort. nV ana m _ ae Nevada Test Sit surrounding States concerning tne pos who may also be involved, the Div ations involved with regard to tae apprehension existing in uy OF as yet unknown populations cho Recognizing the national policy; . 5 use oFmi the COMee: mued “Radiological Health is immedia- po tely reprogramming its epidemioloz i and supportive biomedical and environmental programs to place greater envhasis on tne relative significance of one production of thyroid tumo rs. However, other program commitments Cet 4 1a DUudgetary and personnel ceiilings permit only Limited latitude for such ce direction of effort. TALS amendment would allow furtner expansion of ongoing studies and 4 i Signicicant erlort in tnose imoortant areas oF epidemiology, retrospective dosimetry, and the study of environmental goitrogens in the locales of interest. Without the amendment requested at it is probable that definitive answers will not be round for a period of Five to ten years. With this aqrnendment, resolution of t aeoL poruant questions may be expected within a period of to Tive year. TWO Goals and Program Cosectives In order to clarity tne etiologic importance of radiation in the production of thyroid tumors, there shoulda se coordinated and directed efforts to study various demographic, physiologic and morphologic Factors concommitantiy with radietion exposure Accorcgingly, the Tollowing orcad study objectives are prooosed Tor epiceniologic studies and, wnere aporopriate, for supportive radiobiologic. stucies: (1) To establish vhe prevalence of morbidity and morvality of thy- roid abnormalities in selected irradietea ana comparison human population groups witn concomyitant investigation of ypertinent Tamily and individual nealtn and environmental Tactors. (2) To quantity the relations.ips becwwoen irradiation dose and aducvion of thyroic (3) vunors including the importance of irradiation dose ueLity, and type of radiation and tissue . ; To determine the significance of age at time of exposure of the tnyroie gland in producing thyroid tuners.