a
T. KUMATORI
subjects, i.e. Hiroshima cases, Marshallese, and cases exposed by reactor ac-
«dey at weeip
68
Hematological F
cidents (HEMPELMaNetal., 1952 ; AmaNo, 1953 ; Cronkite et al., 1956 ; Hastercix
and Marineuul, 1956; Gusxova and Batsocotov, 1956; Anprewset al., 1961 ;
Jammet, 1961), it is noted that all these cases similarly revealed the minimal
value at about one month after exposure.
5.
Bone Marrow
The bone marrow was aplastic at the critical stage in severe cases, which
showed remaining and proliferation of plasmacells and reticulum cells. Figure
3 shows the bone marrow of oneof the severe cases. Comparing with normal
eee alarapatren AAEM METI ag Rimr RL. 6a Rime nee
.
kocytes of Bik
Fig. 4 oeumulative).
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Bone marrow of one of severe cases at 5th week.
bone marrow a lack of bone marrow cells was observed. With the beginning of recovery, aplastic marrow changed to hypoplastic and then turned
In some cases, recovery was not complete
lymphocytes, binucleated lymphocytes, vacuoles of neutrophils, toxic granulations
of neutrophils, degenerative changes of blood cells, mitotic abnormalities of
erythroblasts, etc.
Motility and phagocytosis of neutrophils decreased remarkably. After one
year, in some cases these functions were still lower than in normalpersons.
FOLLOW-UP STUDIES
As above mentioned 16 to 18 fishermen have been examined on an annual basis.
Figure 4 shows the changes of the cumulative distribution curves of leuko-
cytes. The curve of critical stage appeared displaced far to the left of the
normal curve, and gradually approached normal values.
However, the curve of the 6th year wasstill displaced slightly to the left
ad Feet
in
Fig. 5 Changes<
cytes. neutrophils
of normal jap
chat e
Morphological and Functional Changes
Several morphological abnormalities were observed: nuclear debris of
the curve app
in the cumula!
pepe SGpindgsi
6.
prepa
even after one year. In less severe cases, the bone marrow was notaplastic
but hypoplastic or in a type of maturation arrest even at thecritical stage.
whan +
into a type of maturation arrest.
However,
the changes of
are represent:
A small i
of erythroble
10 years.
Cytogen
results are S
1. The