~ 5-6 the Nevada test site amounts to 90 thousand man rads, the latter is 1 per cent of the total genetically effective dose from fallout. The total genetically effective dose from fallout is in turn estimated to be 1.66% of average background radiation for the same period. Thus the genetically effective dose to the population around the Nevada test site from past testing is 1/6000 part of the natural dose that would normally be received by the whole United States population. In the over-all increase in harmful mutations it is therefore an exceedingly small fraction. It remains to be considered whether the dose received by any individual in the area of highest exposures warrants great concern. It is estimated that from 100 to 500 persons received whole body exposures of 5 to 6.0 rads during the seven years of testing in Nevada. This is about ten times the exposure from average natural background for the same period. The Committee on Genetic Effects of Atomic Radiation of the National Academy of Sciences has recommended that no individual should receive more than 50r up to age 30. A small number of persons have thus received about 10% of the permissible gonadal exposure for an individual. These same few persons have in six years received up to double the Federal Radiation Council's "basic guide" for whole body radiation. Another way of regarding the probable genetic effect of the maximum doses received by the small group of individual is to consider them in relation to the present load of tangible genetic defects occurring normally without relation to any added radiation. The United Nations Scientific Committee on the Effects of Atomic Radiation estimated that about 4% of all children born have at least one defect on a genetic basis. It further appears that there will be an approximately equal number of children that will exhibit one or more defects of a non-hereditary nature. Thus, normally, 500 persons, one-half of whom are in their reproductive years, might be expected to produce eventually about 350 children among whom there might be 28 with some degree of congenital defect. - From considerations of the doubling dose and the general genetic behavior of developmental mutants, it follows that an additional 5 rad exposure to these 500 individuals would have about 1 chance in 10 of producing 1 additional case of tangible defect in their children; i.e., 29 cases instead of 28. The medical implications of these findings must necessarily be expressed in general terms. Our scientific information is as yet much too incomplete to permit reliable quantitative predictions. We feel that the important point to stress is that these exposures of persons to fallout radiation both internally and externally must be considered in the perspective of natural situations in which substantial numbers of people have lived for periods of time extending to many centuries at background radiation levels several orders of magnitude greater than those under consideration.

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