r - 26 = involved, surface doses of 16,000 rad from a P32 plaque induced an average of 1 cancer/animal which is indicative “nat larcer manmals are similarly susceptible to skin cancer azter intense radiation insult. Again, these gross obser- vations demonstrate that enhanced tumor incidence does occur after very hica doses. Intense localized radiation of the subcutaneous and intraperiteneal tissue of animals by Pu-239 has also been snown to cazse a high frequency of cancer induction43-45, NoW what are these exneriments trying to teil us? results I=- Certainly a reasonable interoretation of these experimental §: when a critical (e.c., a hair follicle) sosage, architectural unit of a tissue is irradiated at a sufficiently high the cnance of it becoming cancerous is approximately ‘ 19-3 t9 1077. This has become known as the "Geesaman -* 3 Palztesc Human Exserience - Since in2 above experiments relate to cancer in¢uction in animals, t4/ iz is pertinent to ask whether man is more or less Sanders, C.L. an@ T.A. Jackson, “Induction of Mesotheliomas andi Sarcenas From ‘Hor Spots' of Pu? Activity," Health Physics, ecol. 22, No. &, June 1972, op. 735-759. "Carcinocenic Properties of 3 and of mp. Plutonium," 361-363. Radiotogy,