ee ee at
N
a burden range of 0.5 uCi
to 50 uCi the observed tumor incidence
fluctuated between 0.04 and 0. 371,
All of these lung experiments involved intense exposures
and a Significant level of carcinogenesis.
Severe damage
and disruption of tissue were associated with the exposures.
The most relevant lung exveriment is Bair's Pu23905
se
.
.
537-
inhalation study with beagles??7°4.
Exposure was to
particulates of 0.25 u or 0.5 u median diameter; burdens were
in the uCi rancse.
Twenty of the 21 dogs thar survived more
than 1600 davs sost exsosure had lung cancer.
cancers
were multicentric in origin.
Many of these
The cancers again
acoeared in conjunction with severe lung intury.
natural incizenc2 of the disease is smell,
Since the
it appears that
at this level of exvosure the induction of ising cancer is a
cerztainty Gurinc the normal beagle life svoan
L/
Cember,
H.,
52°
Sair,
52’
Park, J.F.,
Os.
W.J.,
3.F.
At the same
cit.
Park,
and W.J.
Clarke,
“Long-term
gtude of dinnalec ciutonium in dogs," Battelisa Memorial Institute
(Pictnland}), -PwWL-TR-33-214, 1965 (AD-631 637:.
w.g. Clarke and W.dJ.
Bair,
“Thro
atfects
of intaled 23992535 in beagles," Battelle-Nerinvest Laboratory
Annuil Reoort for 13457 to the USAEC Divisisn sf Biology and
Mec tsinea,
po.
Vol.
I,
Bisalogical
Sciences,
BNWL-714,
1958,
3.3-3.4.
34,
Park, J.F., 22 al, "Proaress in Beacle Sog Studies wi
ransuranium Elerentsat Battella-Northwvest,” Health Phvst
“ed.
22,
No.
6,
Jana
1373,
OQ.
393-3819.
'