-:° 26
=
involved, surface doses of 16,000 rad from a P?* plaque
induced an average of:1 cancer/animal which is indicative
that larger mammals are similarly susceptible to skin cancer
after intense radiation insult.
Again,
these gross obser-
vations demonstrate that enhanced tumor incidence does occur
after very hich doses.
Intense localized radiation of the subcutaneous and
intraperitoneal tissue of animals by Pu-239 has also been
»
43-45.
Shown to cause a high frequency of cancer induction
a”
Now what are these experiments trying to tell us?
oe oe pe ee
Certainly a reasonable interpretation of these experimental
results
(e.g.,
is:
when
a
critical
a hair follicle)
architectural unit of a
tissue
is irradiated at a sufficiently high
dosage,
the chance of it becoming cancerous is approximately
1073
1074.
to
This has
become
known
as
the
“Geesaman
hypothesis."
B
Related Human Experience
Since the above experiments relate to cancer induction
in animals, it is pertinent to ask whether man is more or less
44/
Sanders, C.L. and T.A. Jackson, "Induction of Mesotheliomas
and Sarcomas From ‘Hot Spots' of Pu02 Activity," Health Physics,
Vol. 22, No. 6, June 1972, pp. 755-759.
4s/
Lisco, Herman, et al, “Carcinogenic Properties of
Radloactive Fission Products and of Plutonium,” Radiology,
Vol. 49, No. 3, Sept. 1947, pp. 361-363.
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