These symptoms may also involve the eyes with accompanying lachrymation. As pointed out earlier, fallout of an alkaline nature may contribute to this symtomatclogy. The above symptoms occurred in many of the Marshallese, In more aeverely damaged skin, erythema, edema and areas of blanching may be noted. Erythema was not observed in the Marshallese, perhaps due to the dark color of the skin. _.O+l.,2 LATENT PERIOD, The early signs and symptoms usually disappear within a few days and a relatively asymptomatic latent period ensues. The length of this latent period may vary from a few days to several weeks and is relatec to the dose to the skin; the higher the dose, the shorter the latent period. In the Marshallese, the more heavily exposed group developed lesions about two weeks after exposure, a week earlier than the less heavily exposed groups. ~_..0.1.3 DEVELOPMENT OF GROSS LESIONS. Following the latent period the evidence of skin damage becomes apparent with intensification of signs and symptoma. A secondary wave of erythema may be seen along with gross changes in the skin. Such changes may be in the form of simple tanning or more marked pignen- tation with the formation of macules, papules, or raised plaques of thickened pigmented skin. Mild lesions may cause only sligit itching and burning and superficial desquamation from the center of the lesion outward, leaving depigmented thinned areas of epidermis whic!. gradually repigment and heal the following week or so. In the more heavily exposed Marshallese group of 64 people, about 90 per cent developed miltiple, spotty, pigmented lesions on exposed parts of the body. Wigs. 3, 4, and 5}. and ulceration, eceur. Most of these lesions were superficial in nature (see More severe exposure to the skin results in vesiculation Such lesions may be quite painful and secondary infection may They require longer to heal and may result in some degree of atrophy