eeetie ee RR
cere
A
nee
_—
~268
commenced (Czrcenhite et al., Woods ct al., and Atien).
The control of the bleeding
cid not ancrease the survival rate at the LD-y devel or above.
Taz platelet Level at which biceding may occur spontancously was studied by
Lamezton ct al. in eats.
anemia did not occur.
At paatalet lovels above 40 ,000/mmn® , blecdins and
Simiiasly in hezan beings exposed to fallout with platelet
counts es low as 3$,CCO/am, biceding was not observed (see section..3.6.6),
Lostly, there isa zeal species difference inthe rate of fall of platclets in man
and other mammals (sce section 3.6.6).
8.12
Value of Homstolocic Studics in Prognosis of Acute Radiation Injury. -
From the serial studics of the bicod that bave been discussed, it becomes apparent that there are certrin hematologic simns that can be used as prog-
nostic guides.
None of these prognostic guides is absolute,
The value of hemato-
logic studies in radiation injury may te summarized as follows:
a. A favorscble prognosis is sugsested by an early reticulocytosis, a re-
f the lysaphocyte.
©
=)
a!
Ss
nw
fe)
«a?
~<a
oO
R
4
|
?
f
oO.
turn of platelets, a granulocyte count greater than 1500 per cubic mn.
b. An unfavorable proznosis is suszgested by a complete disappecsrance of
the lymphocytes, granvlocytes oad platelets, and an increase in the
clotting time with the development of puspura and particulacly when
accompanied by fever.
In cninsis, at least, if the favorable prog-
nostic signs listed above do not appear by the 15th to 20th day ofter
empesurce, death is usuci.
The enperiences of the Japanese physicians
poerciicl the above observations, except that recovery occurred more
slowly.
Poor nutrition may bave altescd the natural course of the
disease in the Japanese.
Unfortunately, exceptions occur and it is
impossible to prognosticate accusately the outcome of radictioa illness
C1
on the basis of hemcatolosic signs.