qq
apa et
apanese exposcd at iliroshima and Nazaschi, ond with
the findincss on the human
oc
cings exposed in reactor accidents (sce Lond et cl.).
They are also consistent
with laters findings in patients emposed thagancuticatly eithes to total-body
mecadiation (Miller, Pletchss ond Gerstner; Nickson and Dene), or to internaliy=
adnuinistesed radicnuclides (Wolins).
8.6.6
Splenic, Thymic Weight Docsense.
Caster et al. had previously dcnone
steated a very close corrclation between the cose of radiction and the decrease in
the splenic ond thymic weights on tho Stn dey after exposure to radiation.
These
observations made it possible to use the decrease in splenic thymic weight for
mammalian dosimctry and in studying the effccts
neutralize the effect of radiation.
man and Kohn.
of substances that may primarily
Tris type of study has been extended by Kalle
In their studics the time of minimum woicht and dose sesponse did
not follow a simple relationship.
The
data behave as if there are two independent
cell populations with different sensitivities.
Mowover, thymic. weight § days
after iscadistion was a Lincar function of the lozasitha of the radiation dose, as
show by Carter et al. egrdicr,
biolosical dosimeter.
In theiz boncs the system was very useful as a
Another caseful mathomatical analysis of the weight loss of
the thymus and spicca was that of Stroud et al. who are essentially in agreement
with Carter, Kallcan and Zohn on the basic sclationship and the usefulness of the
pzocedurc:,.
Miscclicncous Studies.
Warren has exphasiced the great instabitity of
the bone marrow in some people who nave been es:posed
(less than 50 r).
to small amcun
cP
8.6.7
Noenshaw, Goodfellow ond Wassen hove 212 romasked upon the sreat
differences in stecin, species, ond individuant ia response to aporomimately the
same dose.
Losenz has domonstrated ¢he creates sensitivity
and the more nniforn
respoase of the inb=sced animals to chronic empocuse to cadictioa.
shown ¢hat humans under treatment for
Goodfellow has
cancer with xadiun, in such a manner that a
large volune of tissue is exposed, respond with an initial leukocytosis.
SOC 41s
His